Aldactone and Fentanyl-100 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Fentanyl-100 (fentanyl). Common drug interactions include abdominal adhesions among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Fentanyl-100. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Fentanyl-100?

Fentanyl-100 has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 7,047 Fentanyl-100 users. Check the latest studies of Fentanyl-100.

On Aug, 13, 2026

49 people who take Aldactone and Fentanyl-100 together, and have interactions are studied.

Aldactone and Fentanyl-100 drug interactions.

What are the common drug interactions of Aldactone and Fentanyl-100, by gender? *:

female:

Abdominal adhesions (inflammation of abdomen)
Aortic valve incompetence
Costochondritis (chest wall pain)
Dyspareunia (painful sexual intercourse)
Ejection fraction decreased (systolic heart failure)
Fibromyalgia (a long-term condition which causes pain all over the body)
Headache (pain in head)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Intestinal obstruction
Ovarian adhesion (bands of scar-like tissue that form between ovary and nearby organ)

male:

Fall
Application site erythema (redness of the skin at application site)
Death
Ascites (accumulation of fluid in the abdominal cavity)
Decreased appetite
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Hyperammonaemia
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Multi-organ failure (multisystem organ failure)

What are the common drug interactions of Aldactone and Fentanyl-100, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cardiomyopathy (weakening of the heart muscle)
Pericardial effusion (fluid around the heart)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

10-19:

Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Lymphocyte stimulation test positive
Pyrexia (fever)
Streptococcal infection

20-29:

n/a

30-39:

Cardiac cirrhosis (is a liver condition caused by chronic heart failure)
Hepatic failure (liver failure)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Metastases to bone (cancer spreads to bone)
Metastases to lung (cancer spreads to lung)

40-49:

Calciphylaxis (is a syndrome with vascular calcium accumulation)
Cardiac failure
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cytomegalovirus infection
Urinary tract infection
White blood cell count decreased
Infected skin ulcer
Diarrhoea
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hyperhidrosis (abnormally increased sweating)

50-59:

Chest pain
Costochondritis (chest wall pain)
Depression
Dyspareunia (painful sexual intercourse)
Ejection fraction decreased (systolic heart failure)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Intestinal obstruction

60+:

Hepatic neoplasm malignant (liver cancer)
Pneumonia
Anxiety
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacteraemia (presence of bacteria in the blood)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Injury
Pulmonary embolism (blockage of the main artery of the lung)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the existing conditions these people have? *

Constipation: 9 people, 18.37%
Hepatic Neoplasm Malignant (liver cancer): 8 people, 16.33%
Pain In Extremity: 8 people, 16.33%
Insomnia (sleeplessness): 7 people, 14.29%
Multiple Myeloma (cancer of the plasma cells): 6 people, 12.24%
High Blood Pressure: 6 people, 12.24%
Depression: 5 people, 10.20%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 5 people, 10.20%
Oedema (fluid collection in tissue): 4 people, 8.16%
Breast Cancer: 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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