Aldactone and Hycodan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Hycodan (homatropine methylbromide; hydrocodone bitartrate). Common drug interactions include adrenal insufficiency among females and pulmonary embolism among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Hycodan. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

On Jul, 20, 2026

16 people who take Aldactone and Hycodan together, and have interactions are studied.

Aldactone and Hycodan drug interactions.

What are the common drug interactions of Aldactone and Hycodan, by gender? *:

female:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Pleural effusion (water on the lungs)
Fatigue (feeling of tiredness)
Anaemia (lack of blood)
Asthma
Blood bilirubin increased

male:

Pulmonary embolism (blockage of the main artery of the lung)
Bacterial infection
Febrile neutropenia (fever with reduced white blood cells)
Generalised oedema (swelling all over the body)
Haematoma (collection of blood outside the blood vessels)
Oxygen saturation decreased
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pleural effusion (water on the lungs)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Viral infection

What are the common drug interactions of Aldactone and Hycodan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Adverse event

40-49:

n/a

50-59:

Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Asthma
Blood bilirubin increased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Malaise (a feeling of general discomfort or uneasiness)
Disease progression
Fatigue (feeling of tiredness)

60+:

Pulmonary embolism (blockage of the main artery of the lung)
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Disease progression
Disease recurrence
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)

What are the existing conditions these people have? *

Renal Cell Carcinoma Stage Unspecified (kidney cancer in unknown stage): 6 people, 37.50%
Pain: 6 people, 37.50%
High Blood Pressure: 5 people, 31.25%
Multiple Myeloma (cancer of the plasma cells): 3 people, 18.75%
Ascites (accumulation of fluid in the abdominal cavity): 3 people, 18.75%
Pain In Extremity: 3 people, 18.75%
Osteoporosis (bones weak and more likely to break): 3 people, 18.75%
Nausea (feeling of having an urge to vomit): 3 people, 18.75%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 3 people, 18.75%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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