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Aldactone and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Naltrexone (naltrexone). Common drug interactions include malaise among females.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Naltrexone. It is created by eHealthMe based on reports of 6 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,060 Aldactone users. Check the latest studies of Aldactone.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,825 Naltrexone users. Check the latest studies of Naltrexone.

On Oct, 20, 2025

6 people who take Aldactone and Naltrexone together, and have interactions are studied.

Aldactone and Naltrexone drug interactions.

What are the common drug interactions of Aldactone and Naltrexone, by gender? *:

female:

  1. Malaise (a feeling of general discomfort or uneasiness)
  2. Abdominal discomfort
  3. Dysarthria (speech disorder)
  4. Fatigue (feeling of tiredness)
  5. Flushing (the warm, red condition of human skin)
  6. Infection
  7. Lymphopenia (an abnormally low level of lymphocytes in the blood)
  8. Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
  9. Mobility decreased (ability to move is reduced)
  10. Nausea (feeling of having an urge to vomit)

male:

n/a

What are the common drug interactions of Aldactone and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  2. Conjunctivitis (pink eye)
  3. Constipation
  4. Drug dependence
  5. Dysarthria (speech disorder)
  6. Fatigue (feeling of tiredness)
  7. Lymphopenia (an abnormally low level of lymphocytes in the blood)
  8. Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
  9. Rebound effect (take-back effect)
  10. Speech disorder

50-59:

  1. Malaise (a feeling of general discomfort or uneasiness)
  2. Abdominal discomfort
  3. Vomiting
  4. Abdominal pain upper
  5. Diarrhoea
  6. Drug intolerance (drug sensitivity)
  7. Flushing (the warm, red condition of human skin)
  8. Mobility decreased (ability to move is reduced)
  9. Nausea (feeling of having an urge to vomit)
  10. Occipital neuralgia (a condition characterized by chronic pain in the upper neck)

60+:

n/a

* Approximation only. Some reports may have incomplete information.

Do you take Aldactone and Naltrexone?

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Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Aldactone and Naltrexone:

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Browse all side effects of Aldactone:

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Browse all side effects of Naltrexone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aldactone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Naltrexone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone and naltrexone (the active ingredients of Aldactone and Naltrexone, respectively), and Aldactone and Naltrexone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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