Aldactone and Sublimaze drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Sublimaze (fentanyl citrate). Common drug interactions include cellulitis among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Sublimaze. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Sublimaze?

Sublimaze has active ingredients of fentanyl citrate. eHealthMe is studying from 560 Sublimaze users. Check the latest studies of Sublimaze.

On Jul, 15, 2026

22 people who take Aldactone and Sublimaze together, and have interactions are studied.

Aldactone and Sublimaze drug interactions.

What are the common drug interactions of Aldactone and Sublimaze, by gender? *:

female:

Cellulitis (infection under the skin)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched)
Communication disorder (speech and language disorder)
Cough
Cyst (a closed sac)
Depression
Diastolic dysfunction
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

male:

Febrile neutropenia (fever with reduced white blood cells)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Apathy
Blood pressure fluctuation
Cardiac failure congestive
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depression

What are the common drug interactions of Aldactone and Sublimaze, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abnormal behaviour
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Apathy
Arrhythmia supraventricular (irregular heartbeat supraventricular origin)
Asthenia (weakness)
Blunted affect (lack of emotional reactivity)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

50-59:

Pulmonary oedema (fluid accumulation in the lungs)
Renal tubular necrosis (death of kidney tubules)
Anxiety
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Emotional distress
Fear
Fluid overload (too much fluid in the blood)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hypervolaemia (abnormally increased volume of blood)
Injury

60+:

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Loss of consciousness
Abdominal discomfort
Anaemia postoperative
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Asthenia (weakness)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Bacteraemia (presence of bacteria in the blood)
Blood albumin decreased

What are the existing conditions these people have? *

Pain: 7 people, 31.82%
Burkitt Lymphoma (cancer of the lymphatic system): 5 people, 22.73%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 18.18%
High Blood Pressure: 3 people, 13.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.64%
Oedema (fluid collection in tissue): 3 people, 13.64%
Itching: 3 people, 13.64%
Blood Pressure Abnormal: 2 people, 9.09%
Cardiac Disorder: 2 people, 9.09%
Constipation: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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