Aldomet and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldomet (methyldopa) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include haematochezia among females and autonomic neuropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Aldomet and Vicodin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Aldomet?

Aldomet has active ingredients of methyldopa. It is often used in high blood pressure. eHealthMe is studying from 2,356 Aldomet users. Check the latest studies of Aldomet.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Aug, 09, 2026

17 people who take Aldomet and Vicodin together, and have interactions are studied.

What are the common drug interactions of Aldomet and Vicodin, by gender? *:

female:

Haematochezia (passage of stools containing blood)
Heart rate irregular
Hip deformity
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Induced labour (prematurely stimulating childbirth in a woman)
Irritable bowel syndrome
Joint swelling

male:

Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Postural hypotension
Dehydration (dryness resulting from the removal of water)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetic nephropathy (diabetic kidney disease)
Discomfort
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)

What are the common drug interactions of Aldomet and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bone pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort
Confusional state
Drug exposure during pregnancy
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Fluid retention (an abnormal accumulation of fluid in the blood)
Haematochezia (passage of stools containing blood)
Hypersensitivity
Induced labour (prematurely stimulating childbirth in a woman)

40-49:

Overweight
Oxygen saturation decreased
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic attack
Pickwickian syndrome (extreme obesity accompanied by sleepiness, hypoventilation, and polycythemia)
Postmenopausal haemorrhage (post-menopausal bleeding)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Rales (an abnormal respiratory sound characterized by fine crackles)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)

50-59:

Agitation (state of anxiety or nervous excitement)
Nausea (feeling of having an urge to vomit)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dystonia (abnormal muscle tone)
Faecal incontinence (a lack of control over passing stool)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Anxiety
Dizziness
Migraine (headache)
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Postural hypotension
Dehydration (dryness resulting from the removal of water)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Agitation (state of anxiety or nervous excitement)
Blood pressure systolic increased
Chest pressure sensation (feeling of pressure on chest)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the existing conditions these people have? *

Muscle Spasms (muscle contraction): 3 people, 17.65%
Stable Angina (a constant chest pain): 2 people, 11.76%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 11.76%
Post-Traumatic Stress Disorder: 2 people, 11.76%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 11.76%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 2 people, 11.76%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 11.76%
Stress And Anxiety: 2 people, 11.76%
Insomnia (sleeplessness): 2 people, 11.76%
Urticaria (rash of round, red welts on the skin that itch intensely): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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