Alesse and Provera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alesse (ethinyl estradiol; levonorgestrel) and Provera (medroxyprogesterone acetate). Common drug interactions include breast cancer among females.

The phase IV clinical study analyzes what interactions people have when they take Alesse and Provera. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Alesse?

Alesse has active ingredients of ethinyl estradiol; levonorgestrel. It is often used in birth control. eHealthMe is studying from 3,353 Alesse users. Check the latest studies of Alesse.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

18 people who take Alesse and Provera together, and have interactions are studied.

What are the common drug interactions of Alesse and Provera, by gender? *:

female:

Breast cancer
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Benign hepatic neoplasm (benign (non-cancerous) tumours of the liver)
Haemorrhage (bleeding)
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Alopecia (absence of hair from areas of the body)
Confusional state
Diarrhoea
Headache (pain in head)
Hypoglycaemia (deficiency of glucose in the bloodstream)

male:

n/a

What are the common drug interactions of Alesse and Provera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Rash
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Alopecia (absence of hair from areas of the body)
Confusional state
Diarrhoea
Headache (pain in head)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Loss of consciousness
Loss of libido (loss of sexual urge)
Metrorrhagia (uterine bleeding at irregular intervals)

30-39:

Benign hepatic neoplasm (benign (non-cancerous) tumours of the liver)
Haemorrhage (bleeding)

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Breast cancer
Breast cancer female
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Pancreatitis (inflammation of pancreas)

50-59:

Breast cancer

60+:

n/a

What are the existing conditions these people have? *

Heavy Or Prolong Menstrual Bleeding: 2 people, 11.11%
Stress And Anxiety: 1 person, 5.56%
Postmenopausal Haemorrhage (post-menopausal bleeding): 1 person, 5.56%
Menopausal Symptoms: 1 person, 5.56%
Insomnia (sleeplessness): 1 person, 5.56%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.56%
High Blood Cholesterol: 1 person, 5.56%
Diabetes: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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