Aleve pm and Advil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve pm (diphenhydramine hydrochloride; naproxen sodium) and Advil (ibuprofen). Common drug interactions include drug ineffective among females and blister among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve pm and Advil. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve pm?

Aleve pm has active ingredients of diphenhydramine hydrochloride; naproxen sodium. eHealthMe is studying from 2,094 Aleve pm users. Check the latest studies of Aleve pm.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,534 Advil users. Check the latest studies of Advil.

On Aug, 11, 2026

16 people who take Aleve pm and Advil together, and have interactions are studied.

What are the common drug interactions of Aleve Pm and Advil, by gender? *:

female:

Drug ineffective
Back pain
Pain in extremity
Abnormal behaviour
Dizziness
Malaise (a feeling of general discomfort or uneasiness)
Psychomotor hyperactivity (feelings of extreme restlessness)
Pulmonary embolism (blockage of the main artery of the lung)
Renal injury (kidney injury)
Tremor (trembling or shaking movements in one or more parts of your body)

male:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cellulitis (infection under the skin)
Pain in extremity
Pyrexia (fever)
Rash erythematous (redness of the skin)
Skin mass
Thyroid disorder (thyroid diseases)
Weight increased
Aggression
Delusional perception (delusional perception describes, confusingly, a true perception, to which a patient attributes a false meaning)

What are the common drug interactions of Aleve Pm and Advil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abnormal behaviour
Hot flush (sudden feelings of heat)

50-59:

Back pain
Pain in extremity

60+:

Drug ineffective
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Pain in extremity
Pyrexia (fever)
Rash erythematous (redness of the skin)
Skin mass
Thyroid disorder (thyroid diseases)
Weight increased
Depression
Dizziness

What are the existing conditions these people have? *

Back Pain: 5 people, 31.25%
Sleep Disorder: 3 people, 18.75%
Infection: 2 people, 12.50%
Depression: 2 people, 12.50%
Cystic Fibrosis (disease of the secretary glands): 2 people, 12.50%
Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 6.25%
Pain In Extremity: 1 person, 6.25%
High Blood Cholesterol: 1 person, 6.25%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 6.25%
Blood Pressure Abnormal: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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