Aleve and Apriso drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Apriso (mesalamine). Common drug interactions include drug ineffective among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Apriso. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Apriso?

Apriso has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 3,439 Apriso users. Check the latest studies of Apriso.

On Aug, 08, 2026

17 people who take Aleve and Apriso together, and have interactions are studied.

What are the common drug interactions of Aleve and Apriso, by gender? *:

female:

Drug ineffective
Asthenia (weakness)
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Pain in extremity
Adhesion
Confusional state
Deafness
Decreased appetite
Electrolyte imbalance

male:

Anaemia (lack of blood)
Drug ineffective
Decreased appetite
Diarrhoea
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Infusion related reaction
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pneumonia

What are the common drug interactions of Aleve and Apriso, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Fatigue (feeling of tiredness)
Constipation
Decreased appetite
Diarrhoea
Drug ineffective
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)

50-59:

Adhesion
Asthenia (weakness)
Confusional state
Decreased appetite
Electrolyte imbalance
Epistaxis (bleed from the nose)
Gastric disorder (disease of stomach)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hepatic steatosis (fatty liver disease)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

60+:

Arthralgia (joint pain)
Drug ineffective
Abdominal pain upper
Anxiety
Aphthous ulcer (mouth ulcer)
Cough
Diarrhoea
Ear infection
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Flushing (the warm, red condition of human skin)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 23.53%
Depression: 4 people, 23.53%
High Blood Pressure: 4 people, 23.53%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 17.65%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 17.65%
Nausea (feeling of having an urge to vomit): 3 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 17.65%
Hypersensitivity: 3 people, 17.65%
Sleep Disorder: 2 people, 11.76%
Sinus Disorder (disease of sinus): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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