Aleve and Dayquil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Dayquil (acetaminophen; dextromethorphan; pseudoephedrine). Common drug interactions include interstitial lung disease among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Dayquil. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Dayquil?

Dayquil has active ingredients of acetaminophen; dextromethorphan; pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 1,815 Dayquil users. Check the latest studies of Dayquil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

55 people who take Aleve and Dayquil together, and have interactions are studied.

What are the common drug interactions of Aleve and Dayquil, by gender? *:

female:

Interstitial lung disease
Malaise (a feeling of general discomfort or uneasiness)
Subcutaneous abscess
Visual acuity reduced (reduced clearness of vision)
Maternal exposure during pregnancy (use of substance during pregnancy)
Migraine (headache)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling

male:

Cardiac failure congestive
Drug exposure during pregnancy
Dyspnoea (difficult or laboured respiration)
Eating disorder
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypospadias (an abnormal condition in males in which the urethra opens on the under surface of the penis)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Injury
Intercostal retraction (inward movement of the muscles between the ribs as a result of reduced pressure in the chest cavity)
Nasal flaring (nostrils widen while a person is breathing)

What are the common drug interactions of Aleve and Dayquil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Pyrexia (fever)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Maternal exposure during pregnancy (use of substance during pregnancy)
Migraine (headache)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling

30-39:

Diarrhoea
Drug ineffective
Insulin-like growth factor increased
Pyrexia (fever)
Infusion related reaction
Pneumonia
Rash
Respiratory disorder (respiratory disease)
Abdominal pain upper
Arthralgia (joint pain)

40-49:

Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)

50-59:

Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder
Neoplasm recurrence (reoccurrence of tumour)
Blood glucose decreased
Impaired gastric emptying
Urticaria (rash of round, red welts on the skin that itch intensely)
Wound infection
Ankle fracture
Anxiety

60+:

Back pain
Blood cholesterol increased
Abdominal discomfort
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Aphonia (inability to produce voice)
Arthralgia (joint pain)
Blindness
Cardiac valve disease (heart valve disease)
Erythema (redness of the skin)
Pain in extremity

What are the existing conditions these people have? *

Depression: 9 people, 16.36%
Multiple Allergies (allergy to multiple agents): 8 people, 14.55%
Constipation: 8 people, 14.55%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 12.73%
Panic Disorder: 7 people, 12.73%
Stress And Anxiety: 7 people, 12.73%
Nasopharyngitis (inflammation of the nasopharynx): 4 people, 7.27%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 7.27%
Dyspnea (difficult or laboured breathing): 4 people, 7.27%
Drowsiness: 4 people, 7.27%

* Approximation only. Some reports may have incomplete information.

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