Aleve and Dilantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Dilantin (phenytoin sodium). Common drug interactions include blister among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Dilantin. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

On Aug, 03, 2026

67 people who take Aleve and Dilantin together, and have interactions are studied.

What are the common drug interactions of Aleve and Dilantin, by gender? *:

female:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood urine present
Breast cancer female
Burning sensation
Cardiovascular disorder (heart diseases)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Confusional state
Conjunctivitis (pink eye)
Constipation
Cystitis (inflammation of the wall of the bladder)

male:

Dehydration (dryness resulting from the removal of water)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Electrocardiogram abnormal
Electrocardiogram st segment elevation
Faeces discoloured
Mitral valve incompetence (inefficient heart valve)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

What are the common drug interactions of Aleve and Dilantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Speech disorder
Tremor (trembling or shaking movements in one or more parts of your body)
Clamminess (moist, sticky, and cold to the touch)
Coma (state of unconsciousness lasting more than six hours)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Mydriasis (a dilation of the pupil)
Paralysis flaccid (abnormal condition characterized by the weakening or the loss of muscle tone)
Petit mal epilepsy (absence seizure)

20-29:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fall
Loss of consciousness
Abdominal pain
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dyskinesia (abnormality or impairment of voluntary movement)
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Drug ineffective
Feeling hot
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity
Rash generalised (rash on most of body parts)

40-49:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Coronary artery atherosclerosis (life-threatening blockages in the arteries of your heart)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Hepatorenal syndrome (renal failure in patients with advanced chronic liver disease)

50-59:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dysarthria (speech disorder)
Fatigue (feeling of tiredness)
Gait abnormal
Tremor (trembling or shaking movements in one or more parts of your body)
Vertigo
Adverse event
Anorectal disorder
Bone disorder
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

60+:

Dehydration (dryness resulting from the removal of water)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Abdominal pain
Abnormal dreams
Blood urine present
Breast cancer female
Burning sensation
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Cystitis (inflammation of the wall of the bladder)
Difficulty in walking

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 7 people, 10.45%
Metastatic Carcinoma Of The Bladder (cancer types can spread to the bladder from other place): 4 people, 5.97%
Headache (pain in head): 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

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