Aleve and Ibuprofen sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Ibuprofen sodium (ibuprofen sodium). Common drug interactions include bronchitis among females and therapeutic response unexpected among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Ibuprofen sodium. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Ibuprofen sodium?

Ibuprofen sodium has active ingredients of ibuprofen sodium. eHealthMe is studying from 322 Ibuprofen sodium users. Check the latest studies of Ibuprofen sodium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

11 people who take Aleve and Ibuprofen sodium together, and have interactions are studied.

Aleve and Ibuprofen sodium drug interactions.

What are the common drug interactions of Aleve and Ibuprofen Sodium, by gender? *:

female:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Suicide attempt
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Hypertension (high blood pressure)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Anxiety
Depression

male:

Therapeutic response unexpected

What are the common drug interactions of Aleve and Ibuprofen Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Suicide attempt
Anxiety
Depression
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

30-39:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Hypertension (high blood pressure)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 100.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 27.27%
Drowsiness: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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