Aleve and Imodium a-d drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Imodium a-d (loperamide hydrochloride). Common drug interactions include upper respiratory tract infection among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Imodium a-d. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Imodium a-d?

Imodium a-d has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 8,944 Imodium a-d users. Check the latest studies of Imodium a-d.

On Jul, 09, 2026

97 people who take Aleve and Imodium a-d together, and have interactions are studied.

Aleve and Imodium a-d drug interactions.

What are the common drug interactions of Aleve and Imodium A-D, by gender? *:

female:

Upper respiratory tract infection
Constipation
Migraine (headache)
Muscle spasms (muscle contraction)
Dizziness
Nasopharyngitis (inflammation of the nasopharynx)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Decreased appetite
White blood cell count decreased
Respiratory tract infection

male:

Fatigue (feeling of tiredness)
Anxiety
Fistula (an abnormal connection or passageway between two)
Gastroenteritis bacterial (inflammation of stomach and intestine by bacterial infection)
Inflammatory bowel disease
Insomnia (sleeplessness)
Mood swings (an extreme or rapid change in mood)
Muscle twitching
Night sweats (sweating in night)
Proctalgia (pain in the rectum)

What are the common drug interactions of Aleve and Imodium A-D, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Anxiety
Arthralgia (joint pain)
Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Depression
Fatigue (feeling of tiredness)
Fistula (an abnormal connection or passageway between two)
Gastroenteritis bacterial (inflammation of stomach and intestine by bacterial infection)
Inflammatory bowel disease

20-29:

n/a

30-39:

n/a

40-49:

Fatigue (feeling of tiredness)
Dyspepsia (indigestion)
Increased appetite
Lower limb fracture
Muscle spasms (muscle contraction)
Affective disorder (mental disorder)
Ammonia increased
Ankle fracture
Anxiety
Blood cholesterol increased

50-59:

Haemoglobin decreased
Intervertebral disc protrusion (spinal disc protrusion)
Nausea (feeling of having an urge to vomit)
Otorrhoea (discharge from the ear)
Ovarian torsion (twisting of ovary)
Panic reaction
Psoriasis (immune-mediated disease that affects the skin)
Pyrexia (fever)
Sleep disorder
Vision blurred

60+:

Fatigue (feeling of tiredness)
Nasopharyngitis (inflammation of the nasopharynx)
Upper respiratory tract infection
Colitis (inflammation of colon)
Multiple allergies (allergy to multiple agents)
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Seasonal allergy (allergic condition due to certain season)
White blood cell count decreased
Anaemia (lack of blood)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 24 people, 24.74%
Sinobronchitis (long lasting paranasal sinusitis with repeated bronchitis): 8 people, 8.25%
Infection: 8 people, 8.25%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 8 people, 8.25%
Acne (skin problems that cause pimples): 8 people, 8.25%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 7.22%
Insomnia (sleeplessness): 7 people, 7.22%
Immunodeficiency Common Variable: 7 people, 7.22%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 5.15%

* Approximation only. Some reports may have incomplete information.

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