Aleve and Msm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Msm (methylsulfonylmethane). Common drug interactions include lung disorder among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Msm. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Msm?

Msm has active ingredients of methylsulfonylmethane. It is often used in joint pain. eHealthMe is studying from 1,210 Msm users. Check the latest studies of Msm.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

46 people who take Aleve and Msm together, and have interactions are studied.

What are the common drug interactions of Aleve and Msm, by gender? *:

female:

Lung disorder (lung disease)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
White blood cell count increased
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Initial insomnia (feeling of inadequate or poor-quality sleep)
Rectal haemorrhage (bleeding from anus)

male:

Depression
Migraine (headache)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)
Surgery
Thrombocytopenia (decrease of platelets in blood)
Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures)
Anxiety
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of Aleve and Msm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Device expulsion

40-49:

Drug ineffective
Surgery

50-59:

Chest discomfort
Somnambulism (sleep walking)
Tooth disorder (tooth disease)
Nausea (feeling of having an urge to vomit)

60+:

Back pain
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Breast mass
Death
Drug hypersensitivity
Drug ineffective
Fatigue (feeling of tiredness)
Glaucoma (increased fluid pressure in the eye with vision loss)
Herpes zoster
Insomnia (sleeplessness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 26 people, 56.52%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 23.91%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 8.70%
Multiple Myeloma (cancer of the plasma cells): 3 people, 6.52%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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