Aleve and Pentasa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Pentasa (mesalamine). Common drug interactions include pneumonia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Pentasa. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

On Jul, 31, 2026

39 people who take Aleve and Pentasa together, and have interactions are studied.

What are the common drug interactions of Aleve and Pentasa, by gender? *:

female:

Pneumonia
Hepatic enzyme increased
Influenza
Dyspnoea (difficult or laboured respiration)
Abdominal pain
Abortion spontaneous (naturally occurring miscarriage)
Blindness unilateral
Diarrhoea
Injection site haemorrhage (bleeding from injection site)
Injection site pain

male:

Dyspnoea (difficult or laboured respiration)
Arthralgia (joint pain)
Cough
Dizziness postural
Drug hypersensitivity
Dyspnoea at rest (difficult or laboured breathing during rest)
Dyspnoea exertional (breathlessness or shortness of breath)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Haemorrhage (bleeding)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

What are the common drug interactions of Aleve and Pentasa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blindness unilateral
Abdominal pain
Blindness transient (sudden loss of vision)
Drug ineffective
Euphoric mood (excessively happy but may become angry or irritable)
Injection site pain
Memory impairment
Optic atrophy (the loss of a proportion of optic disc nerve fibres)
Optic neuritis (optic nerve inflammation)
Rash macular (small, flat red spots)

40-49:

Abortion spontaneous (naturally occurring miscarriage)
Anxiety
Asthenia (weakness)
Chronic kidney disease
Disease progression
Hepatic enzyme increased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Influenza
Influenza like illness
Maternal exposure during pregnancy (use of substance during pregnancy)

50-59:

Haematochezia (passage of stools containing blood)
Abdominal distension
Alopecia (absence of hair from areas of the body)
Dyspnoea (difficult or laboured respiration)
Haemoglobin decreased
Heart rate increased
Large intestinal ulcer haemorrhage (bleeding from large intestine ulcer)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Onychoclasis (breaking of the nails)

60+:

Dyspnoea (difficult or laboured respiration)
Arthralgia (joint pain)
Diarrhoea
Dyspnoea at rest (difficult or laboured breathing during rest)
Epistaxis (bleed from the nose)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Intervertebral disc disorder (spinal disc disorder)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nephrolithiasis (calculi in the kidneys)
Neuropathy peripheral (surface nerve damage)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 10.26%
Joint Pain: 4 people, 10.26%
Diabetes: 4 people, 10.26%
Depression: 4 people, 10.26%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 10.26%
Hypersensitivity: 3 people, 7.69%
Diarrhea: 3 people, 7.69%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 5.13%
Seasonal Allergy (allergic condition due to certain season): 2 people, 5.13%
Nausea (feeling of having an urge to vomit): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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