Aleve and Starlix drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Aleve (naproxen sodium) and Starlix (nateglinide). Common drug interactions include cerebrovascular accident among females and arthralgia among males.
The phase IV clinical study analyzes what interactions people have when they take Aleve and Starlix. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.
What is Aleve?
Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.
What is Starlix?
Starlix has active ingredients of nateglinide. It is often used in diabetes. eHealthMe is studying from 3,768 Starlix users. Check the latest studies of Starlix.
19 people who take Aleve and Starlix together, and have interactions are studied.

What are the common drug interactions of Aleve and Starlix, by gender? *:
female:
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Chronic kidney disease
- Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
- Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
- Blood glucose decreased
- Blood glucose increased
- Cellulitis (infection under the skin)
- Coagulopathy (blood's ability to clot is impaired)
- Death
- Dysgraphia (impaired ability to learn to write)
male:
- Arthralgia (joint pain)
- Constipation
- Hypertension (high blood pressure)
- Intervertebral disc degeneration (spinal disc degeneration)
- Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
- Pain in extremity
- Spinal column stenosis (narrowing of spinal column)
- Abdominal pain
- Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
- Angina pectoris (chest pain due to ischemia of the heart muscle)
What are the common drug interactions of Aleve and Starlix, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Abdominal distension
- Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
- Anaemia (lack of blood)
- Arthralgia (joint pain)
- Cardiac failure congestive
- Congestive cardiomyopathy (weakening of heart muscle)
- Constipation
- Cough
- Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
- Hypercholesterolaemia (high levels of cholesterol in the blood)
60+:
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Muscle spasms (muscle contraction)
- Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
- Chronic kidney disease
- Chronic obstructive airways disease
- Constipation
- Death
- Drug effect increased
- Dysgraphia (impaired ability to learn to write)
- Dyspnoea exertional (breathlessness or shortness of breath)
What are the existing conditions these people have? *
- High Blood Cholesterol: 4 people, 21.05%
- High Blood Pressure: 3 people, 15.79%
- Cardiac Disorder: 3 people, 15.79%
- Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 15.79%
- Insomnia (sleeplessness): 2 people, 10.53%
- Type 2 Diabetes: 2 people, 10.53%
- Headache (pain in head): 2 people, 10.53%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.26%
- Blood Glucose Abnormal: 1 person, 5.26%
- Blood Glucose Increased: 1 person, 5.26%
* Approximation only. Some reports may have incomplete information.
Do you take Aleve and Starlix?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Aleve and Starlix:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Aleve:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Starlix:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Aleve and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Starlix and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on naproxen sodium and nateglinide (the active ingredients of Aleve and Starlix, respectively), and Aleve and Starlix (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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