Aleve and Sublimaze drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Sublimaze (fentanyl citrate). Common drug interactions include disability among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Sublimaze. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Sublimaze?

Sublimaze has active ingredients of fentanyl citrate. eHealthMe is studying from 560 Sublimaze users. Check the latest studies of Sublimaze.

On Jul, 28, 2026

15 people who take Aleve and Sublimaze together, and have interactions are studied.

What are the common drug interactions of Aleve and Sublimaze, by gender? *:

female:

Disability
Dizziness
Fall
Hyperglycaemia (high blood sugar)
Oral disorder (mouth disease)
Adnexa uteri mass (ovarian cysts)
Anaemia (lack of blood)
Arthralgia (joint pain)
Balance disorder
Contusion (a type of hematoma of tissue in which capillaries)

male:

Anxiety
Renal failure (kidney dysfunction)
Alveolitis allergic (inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Appetite disorder (abnormal eating habits)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Atrophic vulvovaginitis (inflammation of the vulva)
Back pain

What are the common drug interactions of Aleve and Sublimaze, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Chronic kidney disease
Emotional distress
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mobility decreased (ability to move is reduced)
Renal cyst (kidney cyst)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Benign intracranial hypertension (benign intracranial hypertension (bih) is a headache syndrome)
Csf pressure increased

40-49:

n/a

50-59:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Necrosis (the death of body tissue)
Neoplasm malignant (cancer tumour)
Oral disorder (mouth disease)
Osteitis (a general term for inflammation of bone)
Osteomyelitis (infection of bone)
Osteomyelitis chronic (long lasting infection of bone marrow)
Osteonecrosis of jaw (death of bone of jaw)
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Abdominal pain
Adnexa uteri mass (ovarian cysts)
Depression
Disability
Dizziness
Ear infection
Excoriation (to tear or wear off the skin of)
Fall
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperglycaemia (high blood sugar)

What are the existing conditions these people have? *

Hiv Infection: 3 people, 20.00%
Hepatitis B: 3 people, 20.00%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 13.33%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 2 people, 13.33%
High Blood Cholesterol: 2 people, 13.33%
Multiple Allergies (allergy to multiple agents): 1 person, 6.67%
Multi-Vitamin Deficiency (lack of vitamins): 1 person, 6.67%
Infection: 1 person, 6.67%
Headache (pain in head): 1 person, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and Sublimaze?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously