Aleve and Valacyclovir hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Valacyclovir hydrochloride (valacyclovir hydrochloride). Common drug interactions include cough among females and abnormal dreams among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

36 people who take Aleve and Valacyclovir hydrochloride together, and have interactions are studied.

Aleve and Valacyclovir hydrochloride drug interactions.

What are the common drug interactions of Aleve and Valacyclovir Hydrochloride, by gender? *:

female:

Cough
Dental caries
Dry throat
Hypoaesthesia (reduced sense of touch or sensation)
Sneezing
Oropharyngeal pain
Spinal stenosis (narrowing of spinal column)
Abortion spontaneous (naturally occurring miscarriage)
Arthralgia (joint pain)
Claustrophobia (fear of having no escape and being closed in small spaces)

male:

Abnormal dreams
Chest pain
Neutropenia (an abnormally low number of neutrophils)
Pain in extremity
Rash
White blood cell count decreased
Disturbance in attention
Feeling jittery
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Snoring

What are the common drug interactions of Aleve and Valacyclovir Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abortion spontaneous (naturally occurring miscarriage)
Claustrophobia (fear of having no escape and being closed in small spaces)
Haemorrhagic disorder (bleeding disorder)
Muscle spasms (muscle contraction)
Spinal stenosis (narrowing of spinal column)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting

50-59:

Abnormal dreams
Abdominal discomfort
Anxiety
Arthralgia (joint pain)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Fatigue (feeling of tiredness)
Fear
Gastric ph decreased

60+:

Fatigue (feeling of tiredness)
Oral herpes (viral infection of mouth)
Dry mouth
Dry skin
Epistaxis (bleed from the nose)
Flatulence (flatus expelled through the anus)
Food poisoning (poison in food)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Haemoglobin decreased
Hypersensitivity

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 21 people, 58.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 33.33%
Drowsiness: 9 people, 25.00%
Stress And Anxiety: 5 people, 13.89%
Multiple Myeloma (cancer of the plasma cells): 3 people, 8.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.56%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.56%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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