Alkeran and Hydrocortisone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alkeran (melphalan) and Hydrocortisone (hydrocortisone). Common drug interactions include polyneuropathy among females and pericarditis among males.

The phase IV clinical study analyzes what interactions people have when they take Alkeran and Hydrocortisone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Alkeran?

Alkeran has active ingredients of melphalan. eHealthMe is studying from 5,429 Alkeran users. Check the latest studies of Alkeran.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

On Aug, 13, 2026

20 people who take Alkeran and Hydrocortisone together, and have interactions are studied.

Alkeran and Hydrocortisone drug interactions.

What are the common drug interactions of Alkeran and Hydrocortisone, by gender? *:

female:

Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Renal cyst (kidney cyst)
Renal failure (kidney dysfunction)
Rhonchi (abnormal breath sounds)
Rib fracture
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinus congestion (blockage of sinus)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tenderness (pain or discomfort when an affected area is touched)

male:

Pericarditis (inflammation of the pericardium)
Antithrombin iii deficiency (rare hereditary disorder that generally comes to light when a patient suffers recurrent venous thrombosis and pulmonary embolism, and repetitive intrauterine fetal death (iufd))
Monoparesis (one limb is very weak, but not completely paralyzed)
Muscular weakness (muscle weakness)
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Neuropathy peripheral (surface nerve damage)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Neutropenia (an abnormally low number of neutrophils)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)

What are the common drug interactions of Alkeran and Hydrocortisone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Antithrombin iii deficiency (rare hereditary disorder that generally comes to light when a patient suffers recurrent venous thrombosis and pulmonary embolism, and repetitive intrauterine fetal death (iufd))
Anxiety
Aphasia (damage to the parts of the brain that control language)
Depressed level of consciousness
Gastritis (inflammation of stomach)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Monoparesis (one limb is very weak, but not completely paralyzed)
Muscular weakness (muscle weakness)
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

10-19:

n/a

20-29:

n/a

30-39:

Acute respiratory distress syndrome
Abdominal distension
Procedural pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anisocytosis (patient's red blood cells are of unequal size)
Anxiety
Asthenia (weakness)
Back pain
Beta 2 microglobulin increased
Blood calcium decreased

40-49:

n/a

50-59:

n/a

60+:

Blood creatinine increased
Blood potassium decreased
Candidiasis (candidiasis or thrush is a fungal infection)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Hypoxia (low oxygen in tissues)
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 2 people, 10.00%
Systemic Mycosis (fungal infections of the body): 1 person, 5.00%
Allergies: 1 person, 5.00%
Bone Marrow Conditioning Regimen: 1 person, 5.00%
Breast Cancer: 1 person, 5.00%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 1 person, 5.00%
Epiglottic Carcinoma (throat cancer): 1 person, 5.00%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 1 person, 5.00%
Immunodeficiency Disorders: 1 person, 5.00%
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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