Alkeran and Medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alkeran (melphalan) and Medrol (methylprednisolone). Common drug interactions include hypoaesthesia among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Alkeran and Medrol. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Alkeran?

Alkeran has active ingredients of melphalan. eHealthMe is studying from 5,429 Alkeran users. Check the latest studies of Alkeran.

What is Medrol?

Medrol has active ingredients of methylprednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,443 Medrol users. Check the latest studies of Medrol.

On Jul, 07, 2026

49 people who take Alkeran and Medrol together, and have interactions are studied.

What are the common drug interactions of Alkeran and Medrol, by gender? *:

female:

Hypoaesthesia (reduced sense of touch or sensation)
Osteomyelitis (infection of bone)
Pain in jaw
Anxiety
Arthralgia (joint pain)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Herpes zoster
Mitral valve incompetence (inefficient heart valve)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neuropathy peripheral (surface nerve damage)

male:

Febrile neutropenia (fever with reduced white blood cells)
Systemic sclerosis (an autoimmune or connective tissue disease. it is characterized by thickening of the skin)
Insomnia (sleeplessness)
Mucous membrane disorder (disease of mucous membrane)
Pyrexia (fever)
Renal disorder (kidney disease)
Aseptic necrosis bone
Aspergillosis (an infection caused by a fungus called aspergillus)
Cytomegalovirus infection
Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury)

What are the common drug interactions of Alkeran and Medrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hypertension (high blood pressure)
Pancreatitis acute (sudden inflammation of pancreas)
Renal failure (kidney dysfunction)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Tonic convulsion (the person will quickly lose consciousness and the skeletal muscles will suddenly tense, often causing the extremities to be pulled towards the body or rigidly pushed away from it)

10-19:

Febrile neutropenia (fever with reduced white blood cells)
Cytomegalovirus test positive
Insomnia (sleeplessness)
Mucous membrane disorder (disease of mucous membrane)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Pyrexia (fever)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Rash

20-29:

n/a

30-39:

Febrile neutropenia (fever with reduced white blood cells)

40-49:

Drug ineffective
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Weight decreased
Abdominal pain upper
Cardiac failure acute
Cardiac failure congestive

50-59:

n/a

60+:

Osteomyelitis (infection of bone)
Diarrhoea
Herpes zoster
Hypertension (high blood pressure)
Mitral valve incompetence (inefficient heart valve)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neuropathy peripheral (surface nerve damage)
Osteopenia (a condition where bone mineral density is lower than normal)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Rhinorrhoea (watery mucus discharge from the nose)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 22 people, 44.90%
Bone Marrow Conditioning Regimen: 8 people, 16.33%
Cytomegalovirus Test Positive: 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

Do you take Alkeran and Medrol?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously