Alkeran and Roxanol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alkeran (melphalan) and Roxanol (morphine sulfate). Common drug interactions include abdominal pain upper among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Alkeran and Roxanol. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Alkeran?

Alkeran has active ingredients of melphalan. eHealthMe is studying from 5,429 Alkeran users. Check the latest studies of Alkeran.

What is Roxanol?

Roxanol has active ingredients of morphine sulfate. eHealthMe is studying from 807 Roxanol users. Check the latest studies of Roxanol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

26 people who take Alkeran and Roxanol together, and have interactions are studied.

What are the common drug interactions of Alkeran and Roxanol, by gender? *:

female:

Abdominal pain upper
Asthenia (weakness)
Beta 2 microglobulin increased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Burning sensation
Cough
Deformity (disfigurement)
Dental caries
Depression
Discomfort

male:

Anxiety
Osteonecrosis of jaw (death of bone of jaw)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Injury
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoporosis (bones weak and more likely to break)
Pleural fibrosis (formation of fibrous tissue in lung)
Post laminectomy syndrome
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)

What are the common drug interactions of Alkeran and Roxanol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Acute respiratory distress syndrome
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anisocytosis (patient's red blood cells are of unequal size)
Anxiety
Asthenia (weakness)
Back pain
Beta 2 microglobulin increased
Blood calcium decreased
Blood glucose increased

40-49:

Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Burning sensation
Cough
Deformity (disfigurement)
Depression
Diarrhoea
Discomfort
Dizziness
Dyspnoea (difficult or laboured respiration)
Emotional distress

50-59:

Anxiety
Arthralgia (joint pain)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Injury
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoporosis (bones weak and more likely to break)
Pleural fibrosis (formation of fibrous tissue in lung)
Post laminectomy syndrome
Renal failure (kidney dysfunction)

60+:

n/a

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 12 people, 46.15%

* Approximation only. Some reports may have incomplete information.

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