Aloe and Norco drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aloe (aloe) and Norco (acetaminophen; hydrocodone bitartrate). Common drug interactions include meningitis aseptic among females and diffuse large b-cell lymphoma among males.

The phase IV clinical study analyzes what interactions people have when they take Aloe and Norco. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Aloe?

Aloe has active ingredients of aloe. eHealthMe is studying from 2,128 Aloe users. Check the latest studies of Aloe.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

55 people who take Aloe and Norco together, and have interactions are studied.

What are the common drug interactions of Aloe and Norco, by gender? *:

female:

Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Dyspnoea (difficult or laboured respiration)
Fall
Diarrhoea
Headache (pain in head)
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Hip fracture
Pain in extremity

male:

Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Drug ineffective
Pain in extremity
Somnolence (a state of near-sleep, a strong desire for sleep)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gait disturbance
Gastric disorder (disease of stomach)
Hip fracture
Lethargy (tiredness)

What are the common drug interactions of Aloe and Norco, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Ear infection
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Nasal ulcer (ulcer of nose)
Nasopharyngitis (inflammation of the nasopharynx)

40-49:

Circadian rhythm sleep disorder (family of sleep disorders affecting, among other things, the timing of sleep)
Depressed mood
Dyspnoea (difficult or laboured respiration)
Gastric disorder (disease of stomach)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)
Stress
Suicidal ideation
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)

50-59:

Abasia (inability to walk)
Anaemia (lack of blood)
Anxiety
Arthralgia (joint pain)
Chest discomfort
Chest pain
Cough
Diarrhoea
Dry skin
Dyspepsia (indigestion)

60+:

Oedema peripheral (superficial swelling)
Pruritus generalised (generalized itching)
Autoimmune hepatitis
Benign lymph node neoplasm (benign (non-cancerous) tumours of the lymph node)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Diarrhoea
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Drug ineffective
Fatigue (feeling of tiredness)
Gait disturbance

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 14 people, 25.45%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 21.82%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 10.91%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 9.09%
Breast Cancer: 5 people, 9.09%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 5.45%
Itching: 3 people, 5.45%
High Blood Pressure: 3 people, 5.45%
Constipation: 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

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