Alphagan and Avapro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alphagan (brimonidine tartrate) and Avapro (irbesartan). Common drug interactions include nausea among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Alphagan and Avapro. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.

What is Avapro?

Avapro has active ingredients of irbesartan. It is often used in high blood pressure. eHealthMe is studying from 19,840 Avapro users. Check the latest studies of Avapro.

On Jul, 15, 2026

58 people who take Alphagan and Avapro together, and have interactions are studied.

What are the common drug interactions of Alphagan and Avapro, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Oedema peripheral (superficial swelling)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Skin warm
Somnolence (a state of near-sleep, a strong desire for sleep)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Increased upper airway secretion
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Productive cough

male:

Weight decreased
Asthenia (weakness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic attack
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Road traffic accident
Abdominal distension
Abdominal pain upper
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asthma

What are the common drug interactions of Alphagan and Avapro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Asthenia (weakness)
Confusional state
Headache (pain in head)
High density lipoprotein decreased
Hyperthyroidism (over activity of the thyroid gland)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic attack
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Weight decreased

50-59:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Drug ineffective
Erectile dysfunction
Feeling hot
Gingival bleeding (bleeding gums)
Haematemesis (vomiting of blood)
Headache (pain in head)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Impaired healing

60+:

Renal failure (kidney dysfunction)
Congestive cardiomyopathy (weakening of heart muscle)
Hyperkalaemia (damage to or disease of the kidney)
Social problem
Cough
Family stress
Injury
Dizziness
Sinus disorder (disease of sinus)
Acute respiratory failure

What are the existing conditions these people have? *

High Blood Cholesterol: 11 people, 18.97%
Pain: 6 people, 10.34%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.34%
Diabetes: 5 people, 8.62%
Cardiac Disorder: 4 people, 6.90%
Asthma: 4 people, 6.90%
Type 2 Diabetes: 3 people, 5.17%
Indigestion: 3 people, 5.17%
Dry Eyes (lack of adequate tears): 3 people, 5.17%
Depression: 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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