Alphagan and Heparin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alphagan (brimonidine tartrate) and Heparin (heparin sodium). Common drug interactions include renal failure among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Alphagan and Heparin. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.

What is Heparin?

Heparin has active ingredients of heparin sodium. It is often used in blood clots. eHealthMe is studying from 92,141 Heparin users. Check the latest studies of Heparin.



On Aug, 12, 2026

84 people who take Alphagan and Heparin together, and have interactions are studied.

Alphagan and Heparin drug interactions.

What are the common drug interactions of Alphagan and Heparin, by gender? *:

female:

  1. Renal failure (kidney dysfunction)
  2. Renal failure acute (rapid kidney dysfunction)
  3. Hypotension (abnormally low blood pressure)
  4. Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
  5. Abdominal pain
  6. Arthralgia (joint pain)
  7. Blood creatinine increased
  8. Blood urea increased
  9. Chills (felling of cold)
  10. Cholangitis (infection of the bile duct)

male:

  1. Renal failure (kidney dysfunction)
  2. Anxiety
  3. Headache (pain in head)
  4. Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
  5. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  6. Renal impairment (severely reduced kidney function)
  7. Renal tubular necrosis (death of kidney tubules)
  8. Sepsis syndrome (a clinical condition of blood infection)
  9. Syncope (loss of consciousness with an inability to maintain postural tone)
  10. Abdominal pain

What are the common drug interactions of Alphagan and Heparin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  2. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  3. Throat irritation
  4. Tonsillar disorder (disease of tonsil)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Asthenia (weakness)
  2. Blood creatinine increased
  3. Blood urea increased
  4. Chills (felling of cold)
  5. Cholangitis (infection of the bile duct)
  6. Decreased appetite
  7. Dysuria (painful or difficult urination)
  8. Headache (pain in head)
  9. Pyelonephritis acute (sudden inflammation of kidney caused by bacteria)
  10. Renal impairment (severely reduced kidney function)

60+:

  1. Renal failure (kidney dysfunction)
  2. Anxiety
  3. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  4. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  5. Chronic kidney disease
  6. Constipation
  7. Renal impairment (severely reduced kidney function)
  8. Renal tubular necrosis (death of kidney tubules)
  9. Sepsis syndrome (a clinical condition of blood infection)
  10. Syncope (loss of consciousness with an inability to maintain postural tone)

What are the existing conditions these people have? *

  1. Constipation: 19 people, 22.62%
  2. Pain: 15 people, 17.86%
  3. High Blood Pressure: 14 people, 16.67%
  4. Diabetes: 14 people, 16.67%
  5. Multiple Myeloma (cancer of the plasma cells): 13 people, 15.48%
  6. Neuralgia (pain in one or more nerves): 8 people, 9.52%
  7. Insomnia (sleeplessness): 8 people, 9.52%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 9.52%
  9. Stress And Anxiety: 7 people, 8.33%
  10. Cardiac Disorder: 6 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Alphagan and Heparin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Alphagan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Heparin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Alphagan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Heparin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on brimonidine tartrate and heparin sodium (the active ingredients of Alphagan and Heparin, respectively), and Alphagan and Heparin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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