Alphagan and Isosorbide dinitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alphagan (brimonidine tartrate) and Isosorbide dinitrate (isosorbide dinitrate). Common drug interactions include flushing among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Alphagan and Isosorbide dinitrate. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

On Aug, 02, 2026

29 people who take Alphagan and Isosorbide dinitrate together, and have interactions are studied.

Alphagan and Isosorbide dinitrate drug interactions.

What are the common drug interactions of Alphagan and Isosorbide Dinitrate, by gender? *:

female:

Flushing (the warm, red condition of human skin)
Headache (pain in head)
Hemiparesis (weakness on one side of the body)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hypotension (abnormally low blood pressure)
Intraocular pressure increased
Muscle spasms (muscle contraction)
Nasopharyngitis (inflammation of the nasopharynx)
Optic nerve injury
Oropharyngeal discomfort (pain or irritation of oropharynx)

male:

Cardiac failure congestive
Renal failure chronic (long lasting kidney dysfunction)
Haemoglobin decreased
Leukocytosis (increased white blood cells)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Nasal discomfort
Pruritus (severe itching of the skin)
Sinusitis (inflammation of sinus)
Confusional state
Eczema asteatotic (severe dry skin- during the winter months and in the elderly)

What are the common drug interactions of Alphagan and Isosorbide Dinitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abasia (inability to walk)
Antinuclear antibody positive
Balance disorder
Blindness
Blood creatinine increased
Blood urea increased
Blood uric acid increased
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Dizziness
Dyspnoea (difficult or laboured respiration)

60+:

Cardiac failure congestive
Renal failure chronic (long lasting kidney dysfunction)
Erythema (redness of the skin)
Oedema peripheral (superficial swelling)
Osteomyelitis (infection of bone)
Pleural effusion (water on the lungs)
Pruritus (severe itching of the skin)
Abdominal distension
Abdominal pain lower
Abdominal pain upper

What are the existing conditions these people have? *

Pain: 3 people, 10.34%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 3 people, 10.34%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 10.34%
High Blood Pressure: 3 people, 10.34%
Chest Pain: 3 people, 10.34%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 10.34%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.90%
Essential Thrombocythaemia (chronic blood cancer): 2 people, 6.90%
Diabetes: 2 people, 6.90%
Depression: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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