Alphagan and Lotrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alphagan (brimonidine tartrate) and Lotrel (amlodipine besylate; benazepril hydrochloride). Common drug interactions include aortic arteriosclerosis among females and aortic arteriosclerosis among males.

The phase IV clinical study analyzes what interactions people have when they take Alphagan and Lotrel. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,571 Lotrel users. Check the latest studies of Lotrel.

On Aug, 08, 2026

48 people who take Alphagan and Lotrel together, and have interactions are studied.

What are the common drug interactions of Alphagan and Lotrel, by gender? *:

female:

Aortic arteriosclerosis (hardening of the aortic arteries)
Blood calcium increased
Blood urea increased
Breast cancer recurrent
Breast hyperplasia (accumulation of abnormal cells in a breast duct)
Dehydration (dryness resulting from the removal of water)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Drug ineffective
Dry skin
Eye infection bacterial

male:

Aortic arteriosclerosis (hardening of the aortic arteries)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Anaemia (lack of blood)
Left ventricular dysfunction
Abdominal distension
Abdominal pain
Abdominal pain upper
Angina pectoris (chest pain due to ischemia of the heart muscle)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Aortic valve incompetence

What are the common drug interactions of Alphagan and Lotrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Breast cancer female
Breast cancer metastatic
Metastases to lymph nodes (cancer spreads to lymph node)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pyrexia (fever)
Thrombocythaemia (an increased number of platelets in the circulating blood)
Abdominal pain
Blood urea increased
Breast cancer recurrent
Breast hyperplasia (accumulation of abnormal cells in a breast duct)

60+:

Oedema peripheral (superficial swelling)
Pain
Pruritus generalised (generalized itching)
Skin discolouration (change of skin colour)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin induration (an abnormally hard spot or area on the skin)
Skin plaque (red, scaly patches to appear on the skin)
Skin tightness
Blood glucose increased
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 14.58%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 14.58%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 8.33%
Osteoporosis (bones weak and more likely to break): 3 people, 6.25%
High Blood Cholesterol: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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