Alphagan and Zolpidem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alphagan (brimonidine tartrate) and Zolpidem (zolpidem tartrate). Common drug interactions include angle closure glaucoma among females and sinusitis among males.

The phase IV clinical study analyzes what interactions people have when they take Alphagan and Zolpidem. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.

What is Zolpidem?

Zolpidem has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 92,695 Zolpidem users. Check the latest studies of Zolpidem.

On Aug, 05, 2026

74 people who take Alphagan and Zolpidem together, and have interactions are studied.

Alphagan and Zolpidem drug interactions.

What are the common drug interactions of Alphagan and Zolpidem, by gender? *:

female:

Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
Application site erythema (redness of the skin at application site)
Application site pruritus (application site severe itching of the skin)
Application site vesicles (small bubble within a cell at application site)
Arthralgia (joint pain)
Asthma
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac arrest
Cataract (clouding of the lens inside the eye)
Cellulitis (infection under the skin)

male:

Sinusitis (inflammation of sinus)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Stomatitis (inflammation of mucous membrane of mouth)
Transient global amnesia (a temporary short-term memory loss)
Pneumonia
Confusional state
Fall
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Back pain

What are the common drug interactions of Alphagan and Zolpidem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood alkaline phosphatase increased
Blood creatinine increased
General physical health deterioration (weak health status)
Herpes zoster
Neutropenia (an abnormally low number of neutrophils)
Pneumonia
Pubis fracture
Renal impairment (severely reduced kidney function)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)

40-49:

Cholangitis (infection of the bile duct)

50-59:

Exostosis (formation of new bone on the surface of a bone)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Palpitations (feelings or sensations that your heart is pounding or racing)
Renal tubular necrosis (death of kidney tubules)
Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

60+:

Confusional state
Chronic kidney disease
Renal failure (kidney dysfunction)
Rhinorrhoea (watery mucus discharge from the nose)
Tumour haemorrhage (bleeding from tumour)
Abdominal pain upper
Angina pectoris (chest pain due to ischemia of the heart muscle)
Cardiac failure congestive
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diarrhoea

What are the existing conditions these people have? *

Depression: 14 people, 18.92%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 18.92%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 13.51%
Hiv Infection: 10 people, 13.51%
High Blood Pressure: 10 people, 13.51%
High Blood Cholesterol: 9 people, 12.16%
Stress And Anxiety: 8 people, 10.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 10.81%
Pain: 7 people, 9.46%
Nausea (feeling of having an urge to vomit): 7 people, 9.46%

* Approximation only. Some reports may have incomplete information.

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