Alphagan and Zylet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alphagan (brimonidine tartrate) and Zylet (loteprednol etabonate; tobramycin). Common drug interactions include eye swelling among females and cardio-respiratory arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Alphagan and Zylet. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.

What is Zylet?

Zylet has active ingredients of loteprednol etabonate; tobramycin. eHealthMe is studying from 493 Zylet users. Check the latest studies of Zylet.



On Jul, 18, 2026

11 people who take Alphagan and Zylet together, and have interactions are studied.

Alphagan and Zylet drug interactions.

What are the common drug interactions of Alphagan and Zylet, by gender? *:

female:

  1. Eye swelling
  2. Eyelid disorder
  3. Ocular hyperaemia (an abnormally large amount of blood in eye)
  4. Visual impairment
  5. Renal tubular necrosis (death of kidney tubules)
  6. Chronic kidney disease
  7. Renal failure (kidney dysfunction)
  8. Erythema of eyelid (redness of the eyelid)

male:

  1. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  2. Hepatic failure (liver failure)
  3. Metastatic gastric cancer (cancer types can spread to the stomach from other place)
  4. Metastases to lymph nodes (cancer spreads to lymph node)
  5. Gastric cancer (stomach cancer)
  6. Gastric cancer stage ii (the tumour has penetrated the outer layer of the stomach. cancer cells have not spread to lymph nodes or other organs)
  7. Gastric cancer stage iv (cancer cells have spread to distant organs)

What are the common drug interactions of Alphagan and Zylet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Metastatic gastric cancer (cancer types can spread to the stomach from other place)
  2. Metastases to lymph nodes (cancer spreads to lymph node)
  3. Gastric cancer (stomach cancer)
  4. Gastric cancer stage ii (the tumour has penetrated the outer layer of the stomach. cancer cells have not spread to lymph nodes or other organs)
  5. Gastric cancer stage iv (cancer cells have spread to distant organs)
  6. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  7. Hepatic failure (liver failure)

60+:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Erythema of eyelid (redness of the eyelid)
  4. Eye swelling
  5. Eyelid disorder
  6. Ocular hyperaemia (an abnormally large amount of blood in eye)
  7. Visual impairment
  8. Renal tubular necrosis (death of kidney tubules)

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 81.82%
  2. Anaemia (lack of blood): 6 people, 54.55%
  3. Hiv Infection: 6 people, 54.55%
  4. High Blood Cholesterol: 6 people, 54.55%
  5. Insomnia (sleeplessness): 6 people, 54.55%
  6. Migraine (headache): 6 people, 54.55%
  7. Dry Mouth: 6 people, 54.55%
  8. Nausea (feeling of having an urge to vomit): 6 people, 54.55%
  9. Diarrhea: 6 people, 54.55%
  10. Depression: 6 people, 54.55%

* Approximation only. Some reports may have incomplete information.

Do you take Alphagan and Zylet?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Alphagan and Zylet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Alphagan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zylet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Alphagan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zylet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on brimonidine tartrate and loteprednol etabonate; tobramycin (the active ingredients of Alphagan and Zylet, respectively), and Alphagan and Zylet (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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