Alprazolam and Avalide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alprazolam (alprazolam) and Avalide (hydrochlorothiazide; irbesartan). Common drug interactions include gait disturbance among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Alprazolam and Avalide. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Alprazolam?

Alprazolam has active ingredients of alprazolam. It is often used in stress and anxiety. eHealthMe is studying from 134,864 Alprazolam users. Check the latest studies of Alprazolam.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

92 people who take Alprazolam and Avalide together, and have interactions are studied.

Alprazolam and Avalide drug interactions.

What are the common drug interactions of Alprazolam and Avalide, by gender? *:

female:

Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Sinusitis (inflammation of sinus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Abdominal distension
Anaemia (lack of blood)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Depression
Emotional distress
Fatigue (feeling of tiredness)

male:

Pain
Nausea (feeling of having an urge to vomit)
Renal failure acute (rapid kidney dysfunction)
Tongue ulceration (ulcers on tongue)
Ulcer
Vomiting
Osteopenia (a condition where bone mineral density is lower than normal)
Body temperature increased
Bone disorder
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)

What are the common drug interactions of Alprazolam and Avalide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Injury
Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Activities of daily living impaired
Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Asthenia (weakness)
Avulsion fracture (bone fracture)
Back pain

50-59:

Renal failure (kidney dysfunction)
Bone disorder
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Rash pruritic (redness with itching)
Renal failure acute (rapid kidney dysfunction)
Tongue ulceration (ulcers on tongue)
Osteopenia (a condition where bone mineral density is lower than normal)
Anaemia (lack of blood)
Body temperature increased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Back pain
Breast cancer
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Depression
Dizziness
Emotional distress

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 23 people, 25.00%
Pain: 17 people, 18.48%
Multiple Myeloma (cancer of the plasma cells): 12 people, 13.04%
Depression: 12 people, 13.04%
Infection: 11 people, 11.96%
High Blood Cholesterol: 11 people, 11.96%
Diarrhea: 9 people, 9.78%
Asthma: 9 people, 9.78%
Muscle Spasms (muscle contraction): 8 people, 8.70%
Sleep Disorder: 7 people, 7.61%

* Approximation only. Some reports may have incomplete information.

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