Alprostadil and Nystatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alprostadil (alprostadil) and Nystatin (nystatin). Common drug interactions include toxic epidermal necrolysis among females and coma among males.

The phase IV clinical study analyzes what interactions people have when they take Alprostadil and Nystatin. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Alprostadil?

Alprostadil has active ingredients of alprostadil. It is often used in erection problems. eHealthMe is studying from 2,653 Alprostadil users. Check the latest studies of Alprostadil.

What is Nystatin?

Nystatin has active ingredients of nystatin. It is often used in thrush. eHealthMe is studying from 33,567 Nystatin users. Check the latest studies of Nystatin.

On Jul, 09, 2026

39 people who take Alprostadil and Nystatin together, and have interactions are studied.

Alprostadil and Nystatin drug interactions.

What are the common drug interactions of Alprostadil and Nystatin, by gender? *:

female:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
White blood cell count increased
Blood cholesterol increased
Blood glucose increased
Blood triglycerides increased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Kidney transplant rejection
Low density lipoprotein increased (cholesterol increased in blood)
Lymphocyte count decreased

male:

Coma (state of unconsciousness lasting more than six hours)
Pneumonia
Pyrexia (fever)
Snoring
Thrombocytopenia (decrease of platelets in blood)
Alanine aminotransferase increased
Appendicitis (inflammation of the appendix)
Arterial rupture
Aspartate aminotransferase increased
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)

What are the common drug interactions of Alprostadil and Nystatin, by age (0-1 to 60+)? *:

0-1:

Injection site haemorrhage (bleeding from injection site)
Post procedural haemorrhage (post procedural bleeding)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

2-9:

n/a

10-19:

n/a

20-29:

Coma (state of unconsciousness lasting more than six hours)
Hepatic failure (liver failure)
Hiv test positive
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Laboratory test abnormal
Overdose
Renal failure acute (rapid kidney dysfunction)

30-39:

White blood cell count increased
Blood cholesterol increased
Blood glucose increased
Blood triglycerides increased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Kidney transplant rejection
Low density lipoprotein increased (cholesterol increased in blood)
Lymphocyte count decreased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Protein urine present

40-49:

Blood bilirubin increased
Blood fibrinogen decreased
Coma (state of unconsciousness lasting more than six hours)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematoma (collection of blood outside the blood vessels)
Headache (pain in head)
Pupil fixed
Snoring
Thrombocytopenia (decrease of platelets in blood)

50-59:

Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Epidermal necrolysis (skin condition that is usually caused by a reaction to drugs)
Gastroenteritis (inflammation of stomach and intestine)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Erythema (redness of the skin)
International normalised ratio increased
Pyrexia (fever)

60+:

Pneumonia
Prostate cancer metastatic
Depression
Diarrhoea
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Haemorrhage (bleeding)
International normalised ratio increased
Suicidal ideation

What are the existing conditions these people have? *

Poor Peripheral Circulation: 10 people, 25.64%
High Blood Pressure: 7 people, 17.95%
Oedema (fluid collection in tissue): 7 people, 17.95%
Pain: 7 people, 17.95%
Hypokalemia (low potassium): 6 people, 15.38%
Pneumonia: 6 people, 15.38%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 6 people, 15.38%
Hyperglycemia (high blood sugar): 6 people, 15.38%
Nausea (feeling of having an urge to vomit): 6 people, 15.38%
Heart Disease: 6 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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