Alrex and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alrex (loteprednol etabonate) and Diphen (diphenhydramine hydrochloride). Common drug interactions include drug ineffective among females and systemic lupus erythematosus among males.

The phase IV clinical study analyzes what interactions people have when they take Alrex and Diphen. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Alrex?

Alrex has active ingredients of loteprednol etabonate. eHealthMe is studying from 663 Alrex users. Check the latest studies of Alrex.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 16, 2026

35 people who take Alrex and Diphen together, and have interactions are studied.

What are the common drug interactions of Alrex and Diphen, by gender? *:

female:

Drug ineffective
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Infusion related reaction
Nausea (feeling of having an urge to vomit)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Dyspepsia (indigestion)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Procedural pain

male:

Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Allergen nos skin test positive
Conjunctivitis (pink eye)
Cough
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Earache (ear pain)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema seborrhoeic (seborrhoea and greasy scales on the scalp or eyelids or other parts of the skin)

What are the common drug interactions of Alrex and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Allergen nos skin test positive
Antinuclear factor positive
Arthralgia (joint pain)
Blood immunoglobulin e increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardiomegaly (increased size of heart than normal)
Chest pain
Concussion (short loss of normal brain function in response to a head injury)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Drug ineffective
Infusion related reaction
Pyrexia (fever)
Weight decreased
Abdominal pain
Anaemia (lack of blood)
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Constipation
Erythema (redness of the skin)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 19 people, 54.29%
Allergies: 18 people, 51.43%
Immunodeficiency Common Variable: 10 people, 28.57%
Combined Immunodeficiency: 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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