Amantadine and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amantadine (amantadine) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include foot fracture among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Amantadine and Hydroxyzine. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Amantadine?

Amantadine has active ingredients of amantadine. eHealthMe is studying from 2,261 Amantadine users. Check the latest studies of Amantadine.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

36 people who take Amantadine and Hydroxyzine together, and have interactions are studied.

Amantadine and Hydroxyzine drug interactions.

What are the common drug interactions of Amantadine and Hydroxyzine, by gender? *:

female:

Foot fracture
Fungal infection
Gallbladder disorder
Gastrointestinal ulcer
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pruritus (severe itching at infusion site)
Injection site extravasation (flow of (blood or lymph) from injection site)
Loss of consciousness

male:

Dehydration (dryness resulting from the removal of water)
Drug hypersensitivity
Gait disturbance
Pain
Syncope (loss of consciousness with an inability to maintain postural tone)
Infusion related reaction
Abdominal discomfort
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Bladder disorder

What are the common drug interactions of Amantadine and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dehydration (dryness resulting from the removal of water)
Drug hypersensitivity
Headache (pain in head)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Upper limb fracture
Anaemia (lack of blood)
Blood pressure decreased
Dizziness
Hallucination (an experience involving the perception of something not present)

20-29:

Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Heart rate decreased
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Nasopharyngitis (inflammation of the nasopharynx)
Pain
Photophobia (extreme sensitivity to light)
Respiratory tract infection

30-39:

Alopecia (absence of hair from areas of the body)
Ear pruritus (pruritus or itching is ""the unpleasant skin sensation that frequently provokes scratching"" in ear)
Fatigue (feeling of tiredness)
Tendon disorder (disease of tendon)
Throat irritation

40-49:

Fungal infection

50-59:

Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Hypertensive emergency
Nonspecific reaction (unspecified reaction)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

60+:

Parkinson's disease
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Pneumonia
Resting tremor (an involuntary somewhat rhythmic, muscle contraction and relaxation during resting condition)
White blood cell count increased
Leukocytosis (increased white blood cells)
Hallucination (an experience involving the perception of something not present)
Hallucination, visual (seeing things that aren't there)
Bradycardia (abnormally slow heart action)
Cardiovascular insufficiency (inadequate functioning of heart)

What are the existing conditions these people have? *

Parkinson's Disease: 12 people, 33.33%
Depression: 6 people, 16.67%
Sleep Disorder: 6 people, 16.67%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 5 people, 13.89%
Bipolar Disorder (mood disorder): 5 people, 13.89%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 5 people, 13.89%
Insomnia (sleeplessness): 4 people, 11.11%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 11.11%
Hallucinations, Mixed (sensations that appear real but are created by your mind -mixed): 4 people, 11.11%
Pneumonia: 4 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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