Amaryl and Simcor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amaryl (glimepiride) and Simcor (niacin; simvastatin). Common drug interactions include pruritus among females and blood glucose increased among males.

The phase IV clinical study analyzes what interactions people have when they take Amaryl and Simcor. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Amaryl?

Amaryl has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 32,259 Amaryl users. Check the latest studies of Amaryl.

What is Simcor?

Simcor has active ingredients of niacin; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 11,604 Simcor users. Check the latest studies of Simcor.

On Jul, 13, 2026

24 people who take Amaryl and Simcor together, and have interactions are studied.

What are the common drug interactions of Amaryl and Simcor, by gender? *:

female:

Pruritus (severe itching of the skin)
Injection site discharge
Lymphoedema (localized fluid retention and tissue swelling)
Upper limb fracture
Abdominal discomfort
Abdominal pain upper
Chills (felling of cold)
Constipation
Cystitis (inflammation of the wall of the bladder)
Decreased appetite

male:

Blood glucose increased
Flushing (the warm, red condition of human skin)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chronic kidney disease
Drug ineffective
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Headache (pain in head)
Hypokalaemia (low potassium)
Low density lipoprotein increased (cholesterol increased in blood)
Nervousness

What are the common drug interactions of Amaryl and Simcor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood glucose increased
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Diarrhoea
Ear infection
Feeling jittery
Abdominal pain upper
Dyspepsia (indigestion)
Headache (pain in head)

50-59:

Flushing (the warm, red condition of human skin)
Hot flush (sudden feelings of heat)
Constipation

60+:

Blood glucose increased
Erythema (redness of the skin)
Diarrhoea
Drug ineffective
Hot flush (sudden feelings of heat)
Hypokalaemia (low potassium)
Low density lipoprotein increased (cholesterol increased in blood)
Pain in jaw
Rash macular (small, flat red spots)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Low Density Lipoprotein Increased (cholesterol increased in blood): 5 people, 20.83%
High Density Lipoprotein Decreased: 5 people, 20.83%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 8.33%
High Blood Pressure: 2 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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