Ambien and Hysingla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ambien (zolpidem tartrate) and Hysingla (hydrocodone bitartrate). Common drug interactions include rheumatoid arthritis among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Ambien and Hysingla. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

What is Hysingla?

Hysingla has active ingredients of hydrocodone bitartrate. eHealthMe is studying from 32,609 Hysingla users. Check the latest studies of Hysingla.

On Jul, 09, 2026

41 people who take Ambien and Hysingla together, and have interactions are studied.

What are the common drug interactions of Ambien and Hysingla, by gender? *:

female:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Drug ineffective
Blindness
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug dependence
Gastric ulcer (stomach ulcer)
Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
Sinusitis (inflammation of sinus)
Tremor (trembling or shaking movements in one or more parts of your body)
Vision blurred

male:

Anxiety
Decreased appetite
Back pain
Blood cholesterol increased
Depression
Drug dependence
Muscle tightness
Neck pain
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Benign prostatic hyperplasia (benign enlargement of the prostate)

What are the common drug interactions of Ambien and Hysingla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal discomfort
Aphasia (damage to the parts of the brain that control language)
Blood pressure increased
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Decreased appetite
Dependence
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry mouth

50-59:

Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
Sinusitis (inflammation of sinus)
Vision blurred
Drug ineffective
Blindness unilateral
Immunodeficiency
Blindness
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

60+:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Depression
Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Respiration (transport of oxygen from the outside air to the cells within tissues)
Thrombosis (formation of a blood clot inside a blood vessel)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 46.34%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 19 people, 46.34%
Drowsiness: 7 people, 17.07%
Pain: 6 people, 14.63%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 12.20%
Stress And Anxiety: 3 people, 7.32%
Sleep Disorder: 3 people, 7.32%
Multiple Myeloma (cancer of the plasma cells): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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