Ambien and Percodan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ambien (zolpidem tartrate) and Percodan (aspirin; oxycodone hydrochloride; oxycodone terephthalate). Common drug interactions include fatigue among females and bone disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Ambien and Percodan. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

What is Percodan?

Percodan has active ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate. It is often used in pain. eHealthMe is studying from 12,885 Percodan users. Check the latest studies of Percodan.

On Jul, 14, 2026

39 people who take Ambien and Percodan together, and have interactions are studied.

What are the common drug interactions of Ambien and Percodan, by gender? *:

female:

Fatigue (feeling of tiredness)
Headache (pain in head)
Abdominal pain
Abdominal sepsis (abdominal infection)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Asthenia (weakness)
Breath odour
Cachexia (loss of weight)
Cellulitis (infection under the skin)

male:

Bone disorder
Fatigue (feeling of tiredness)
Bone formation increased
Buccal mucosal roughening
Chest pain
Depression
Drug hypersensitivity
Headache (pain in head)
Impaired healing
Inflammation

What are the common drug interactions of Ambien and Percodan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Nonspecific reaction (unspecified reaction)

30-39:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Sweating increased (excess sweating)
Thinking abnormal
Anxiety
Back pain
Depression
Disturbance in attention
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Loss of consciousness

40-49:

Rash
Weight increased

50-59:

Nasal disorder (diseases of nose)
Obstruction
Osteonecrosis of jaw (death of bone of jaw)
Paranasal sinus mucosal hypertrophy (paranasal sinus mucosal enlargement from the increase in size of its cells)
Sinus disorder (disease of sinus)
Atrophic vulvovaginitis (inflammation of the vulva)
Arthropathy
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dry eye (lack of adequate tears)
Intervertebral disc protrusion (spinal disc protrusion)

60+:

Depression
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Chronic obstructive airways disease
Compression fracture (fracture due to pressure caused by injury)
Delirium (wild excitement)
Fear
Head injury

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 12.82%
Muscle Spasms (muscle contraction): 3 people, 7.69%
Migraine (headache): 3 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.69%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 5.13%
Neuralgia (pain in one or more nerves): 2 people, 5.13%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.13%
High Blood Pressure: 2 people, 5.13%
High Blood Cholesterol: 2 people, 5.13%
Depression: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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