Amifostine and Mitoxantrone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amifostine (amifostine) and Mitoxantrone (mitoxantrone hydrochloride). Common drug interactions include chronic sinusitis among females and acute myeloid leukaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Amifostine and Mitoxantrone. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Amifostine?

Amifostine has active ingredients of amifostine. eHealthMe is studying from 425 Amifostine users. Check the latest studies of Amifostine.

What is Mitoxantrone?

Mitoxantrone has active ingredients of mitoxantrone hydrochloride. eHealthMe is studying from 8,125 Mitoxantrone users. Check the latest studies of Mitoxantrone.

On Jul, 15, 2026

27 people who take Amifostine and Mitoxantrone together, and have interactions are studied.

Amifostine and Mitoxantrone drug interactions.

What are the common drug interactions of Amifostine and Mitoxantrone, by gender? *:

female:

Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Disturbance in attention
Gallbladder polyp (growths or lesions resembling growths (polypoid lesions) in the wall of the gallbladder)
Mobility decreased (ability to move is reduced)
Stomatitis (inflammation of mucous membrane of mouth)
Surgery
Tooth extraction
Wound
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Dyspnoea (difficult or laboured respiration)

male:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Bleeding time prolonged
Pneumonia
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Splenomegaly (enlargement of spleen)
Thrombocytopenia (decrease of platelets in blood)
Full blood count decreased
Infection
Laboratory test abnormal

What are the common drug interactions of Amifostine and Mitoxantrone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Ascites (accumulation of fluid in the abdominal cavity)
Blood bilirubin increased
Coma (state of unconsciousness lasting more than six hours)
Hypoxia (low oxygen in tissues)
Abdominal distension
Abdominal pain
Acute respiratory distress syndrome
Alanine aminotransferase increased
Ammonia increased
Aspartate aminotransferase increased

50-59:

Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Disturbance in attention
Mobility decreased (ability to move is reduced)
Stomatitis (inflammation of mucous membrane of mouth)
Surgery
Tooth extraction
Wound
Gallbladder polyp (growths or lesions resembling growths (polypoid lesions) in the wall of the gallbladder)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Migraine (headache)

60+:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Bleeding time prolonged
Pneumonia
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Splenomegaly (enlargement of spleen)
Thrombocytopenia (decrease of platelets in blood)
Full blood count decreased
Infection
Laboratory test abnormal

What are the existing conditions these people have? *

Ovarian Cancer (cancer of ovary): 21 people, 77.78%
Neoplasm Malignant (cancer tumour): 21 people, 77.78%
Migraine (headache): 21 people, 77.78%
Hot Flush (sudden feelings of heat): 21 people, 77.78%
Discomfort: 21 people, 77.78%
Breast Cancer Metastatic: 21 people, 77.78%
Breast Cancer: 21 people, 77.78%
Granulocyte Count Decreased: 20 people, 74.07%

* Approximation only. Some reports may have incomplete information.

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