Amitiza and Adempas drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitiza (lubiprostone) and Adempas (riociguat). Common drug interactions include abdominal distension among females.

The phase IV clinical study analyzes what interactions people have when they take Amitiza and Adempas. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Adempas?

Adempas has active ingredients of riociguat. eHealthMe is studying from 29,741 Adempas users. Check the latest studies of Adempas.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

12 people who take Amitiza and Adempas together, and have interactions are studied.

What are the common drug interactions of Amitiza and Adempas, by gender? *:

female:

Abdominal distension
Chest pain
Headache (pain in head)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Bacteraemia (presence of bacteria in the blood)
Blood potassium increased
Blood pressure systolic decreased
Fatigue (feeling of tiredness)

male:

n/a

What are the common drug interactions of Amitiza and Adempas, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Blood potassium increased
Blood pressure systolic decreased
Cough
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Fluid overload (too much fluid in the blood)
Fluid retention (an abnormal accumulation of fluid in the blood)
Myalgia (muscle pain)

30-39:

n/a

40-49:

Blood potassium decreased
Confusional state
Lethargy (tiredness)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Renal disorder (kidney disease)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection

50-59:

n/a

60+:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Colon cancer
Renal failure (kidney dysfunction)
Bacteraemia (presence of bacteria in the blood)
Chest pain
Fibromyalgia (a long-term condition which causes pain all over the body)
Kidney infection
Hypotension (abnormally low blood pressure)
Ascites (accumulation of fluid in the abdominal cavity)
Compression fracture (fracture due to pressure caused by injury)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 58.33%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 6 people, 50.00%
Anaemia (lack of blood): 4 people, 33.33%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 2 people, 16.67%
Cardiac Failure: 2 people, 16.67%
Dyslipidaemia (abnormal amount of lipids): 2 people, 16.67%
Gastritis - Chronic (long lasting inflammation of stomach): 2 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
Headache (pain in head): 2 people, 16.67%
Hepatic Failure (liver failure): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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