Amitiza and Gentamicin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitiza (lubiprostone) and Gentamicin (gentamicin sulfate). Common drug interactions include pain in extremity among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Amitiza and Gentamicin. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Gentamicin?

Gentamicin has active ingredients of gentamicin sulfate. It is often used in urinary tract infection. eHealthMe is studying from 21,654 Gentamicin users. Check the latest studies of Gentamicin.

On Jul, 05, 2026

56 people who take Amitiza and Gentamicin together, and have interactions are studied.

Amitiza and Gentamicin drug interactions.

What are the common drug interactions of Amitiza and Gentamicin, by gender? *:

female:

Pain in extremity
Pyelonephritis chronic (chronic inflammation of kidney caused by bacteria)
Pyrexia (fever)
Renal disorder (kidney disease)
Renal hypertension (high blood pressure caused by the kidneys hormonal response)
Renal impairment (severely reduced kidney function)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Swelling face
Toothache (tooth pain)
Sinusitis (inflammation of sinus)

male:

Renal failure (kidney dysfunction)
Abdominal pain
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Hyperhidrosis (abnormally increased sweating)
Hypoaesthesia (reduced sense of touch or sensation)
Oedema (fluid collection in tissue)
Pain in extremity
Retinal haemorrhage (bleeding from retina)

What are the common drug interactions of Amitiza and Gentamicin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Local swelling (swelling at the site of some application of substance or injury)
Swelling face

30-39:

Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal hypertension (high blood pressure caused by the kidneys hormonal response)
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

40-49:

Hypoaesthesia (reduced sense of touch or sensation)
Infusion site infection
Sinusitis (inflammation of sinus)
Blood pressure increased
Eye pain
Headache (pain in head)
Pain
Vulvovaginal mycotic infection (vulvovaginal fungal infection)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Fall

50-59:

Chronic kidney disease
Surgery
Fall
Femur fracture
Fungal infection
Gait disturbance
Gastrointestinal infection (infection of stomach and intestine)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrolithiasis (calculi in the kidneys)

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Cholecystitis acute (rapid infection of gallbladder)
Haemoglobin decreased
Hypotension (abnormally low blood pressure)
Platelet count decreased
Pneumonia
White blood cell count decreased
Cerebral haemorrhage (bleeding within the brain)
Decreased appetite
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 19 people, 33.93%
Pain: 15 people, 26.79%
Immunodeficiency Common Variable: 14 people, 25.00%
Infection: 10 people, 17.86%
Depression: 9 people, 16.07%
Stress And Anxiety: 9 people, 16.07%
Nausea (feeling of having an urge to vomit): 9 people, 16.07%
Migraine (headache): 9 people, 16.07%
Insomnia (sleeplessness): 8 people, 14.29%
High Blood Cholesterol: 8 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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