Amitiza and Inderal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitiza (lubiprostone) and Inderal (propranolol hydrochloride). Common drug interactions include drug hypersensitivity among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Amitiza and Inderal. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Inderal?

Inderal has active ingredients of propranolol hydrochloride. It is often used in migraine. eHealthMe is studying from 16,771 Inderal users. Check the latest studies of Inderal.

On Jul, 16, 2026

59 people who take Amitiza and Inderal together, and have interactions are studied.

What are the common drug interactions of Amitiza and Inderal, by gender? *:

female:

Drug hypersensitivity
Abdominal pain
Borderline personality disorder
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Dyspnoea (difficult or laboured respiration)
Intervertebral disc protrusion (spinal disc protrusion)
Sinusitis (inflammation of sinus)
Viral infection
Insomnia (sleeplessness)
Blood potassium increased

male:

Asthenia (weakness)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Renal impairment (severely reduced kidney function)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Tooth injury
Tooth loss
Abdominal adhesions (inflammation of abdomen)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ankle fracture

What are the common drug interactions of Amitiza and Inderal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Headache (pain in head)

20-29:

Blood phosphorus decreased
Drug hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Oxygen saturation decreased
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)
Vomiting
White blood cell count increased

30-39:

Cough
Fatigue (feeling of tiredness)
Pain
Upper-airway cough syndrome

40-49:

Back pain
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Drug ineffective
General physical health deterioration (weak health status)
Suicidal ideation
Borderline personality disorder
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Depression
Intervertebral disc protrusion (spinal disc protrusion)
Myalgia (muscle pain)

50-59:

Pain
Pericardial effusion (fluid around the heart)
Pneumonia
Pulmonary oedema (fluid accumulation in the lungs)
Renal impairment (severely reduced kidney function)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Sinusitis (inflammation of sinus)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Spinal column stenosis (narrowing of spinal column)

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dyspnoea (difficult or laboured respiration)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ankle fracture
Aphonia (inability to produce voice)
Arrhythmia (irregular heartbeat)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Asthma

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 21 people, 35.59%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 21 people, 35.59%
Depression: 11 people, 18.64%
Stress And Anxiety: 9 people, 15.25%
Neuralgia (pain in one or more nerves): 7 people, 11.86%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 11.86%
Pain: 6 people, 10.17%
Joint Pain: 5 people, 8.47%
Irritable Bowel Syndrome: 5 people, 8.47%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 5 people, 8.47%

* Approximation only. Some reports may have incomplete information.

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