Amitiza and Medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitiza (lubiprostone) and Medrol (methylprednisolone). Common drug interactions include gallbladder disorder among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Amitiza and Medrol. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Medrol?

Medrol has active ingredients of methylprednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,443 Medrol users. Check the latest studies of Medrol.

On Jul, 17, 2026

40 people who take Amitiza and Medrol together, and have interactions are studied.

What are the common drug interactions of Amitiza and Medrol, by gender? *:

female:

Gallbladder disorder
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gingivitis (inflammation of gums)
Hyperhidrosis (abnormally increased sweating)
Injection site pain
Injection site reaction
Joint instability (a condition in which the joints aren't sufficiently supported)
Loose tooth
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

male:

Chronic kidney disease
Death
Haematocrit decreased
Haemoglobin decreased
Hospitalisation
Hyperhidrosis (abnormally increased sweating)
Mean cell haemoglobin increased (more than normal haemoglobin per red blood cell in a sample of blood)
Mean cell volume increased (more than normal average red blood cell volume)
Mood altered (changes in mood)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

What are the common drug interactions of Amitiza and Medrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder disorder

30-39:

Chronic kidney disease
Dyspepsia (indigestion)
Gastritis (inflammation of stomach)

40-49:

Chronic kidney disease
Drug effect increased
Nausea (feeling of having an urge to vomit)
Nephropathy (damage to or disease of a kidney)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

Renal failure (kidney dysfunction)
Abdominal pain
Alanine aminotransferase increased
Antinuclear antibody positive
Arthralgia (joint pain)
Aspartate aminotransferase increased
Asthenia (weakness)
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood alkaline phosphatase increased

60+:

Subcutaneous haematoma (collection of blood outside the blood vessels on the skin)
Gastric ulcer (stomach ulcer)
Blood glucose increased
Chest pain
Cough
Death
Dental caries
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspepsia (indigestion)
Gingivitis (inflammation of gums)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 15.00%
Pain: 5 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 12.50%
Prostate Cancer: 4 people, 10.00%
Infection: 4 people, 10.00%
Indigestion: 3 people, 7.50%
Flatulence (flatus expelled through the anus): 3 people, 7.50%
High Blood Pressure: 3 people, 7.50%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 5.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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