Amitiza and Pacerone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitiza (lubiprostone) and Pacerone (amiodarone hydrochloride). Common drug interactions include cataract among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Amitiza and Pacerone. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Pacerone?

Pacerone has active ingredients of amiodarone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 2,814 Pacerone users. Check the latest studies of Pacerone.

On Jul, 19, 2026

11 people who take Amitiza and Pacerone together, and have interactions are studied.

What are the common drug interactions of Amitiza and Pacerone, by gender? *:

female:

Cataract (clouding of the lens inside the eye)
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Electrolyte imbalance
Emotional disorder

male:

Abdominal discomfort
Dementia (madness)
Dry eye (lack of adequate tears)
Osteoporosis (bones weak and more likely to break)
Parkinson's disease

What are the common drug interactions of Amitiza and Pacerone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Electrolyte imbalance
Emotional disorder
Fear
Gastroenteritis (inflammation of stomach and intestine)
Heart rate decreased
Hypertension (high blood pressure)
Hyperthyroidism (over activity of the thyroid gland)
Hypoaesthesia (reduced sense of touch or sensation)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 54.55%
High Blood Cholesterol: 3 people, 27.27%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 18.18%
Sleep Disorder: 1 person, 9.09%
Pain: 1 person, 9.09%
Gout (uric acid crystals building up in the body): 1 person, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%
Dementia (madness): 1 person, 9.09%
Cardiac Disorder: 1 person, 9.09%
Affective Disorder (mental disorder): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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