Amitiza and Revatio drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitiza (lubiprostone) and Revatio (sildenafil citrate). Common drug interactions include brain natriuretic peptide increased among females and hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Amitiza and Revatio. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Revatio?

Revatio has active ingredients of sildenafil citrate. It is often used in pulmonary hypertension. eHealthMe is studying from 44,849 Revatio users. Check the latest studies of Revatio.

On Jul, 28, 2026

49 people who take Amitiza and Revatio together, and have interactions are studied.

What are the common drug interactions of Amitiza and Revatio, by gender? *:

female:

Brain natriuretic peptide increased
Bowel movement irregularity
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Head discomfort
Hot flush (sudden feelings of heat)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Scleroderma (hard skin)
Temperature regulation disorder (body is unable to maintain temperature)
Left ventricular failure (left ventricle fails to contract forcefully)
Oedema peripheral (superficial swelling)

male:

Hypersensitivity
Anaemia (lack of blood)
Cardiac failure
Haemoglobin decreased
Hospitalisation

What are the common drug interactions of Amitiza and Revatio, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pain in jaw
Platelet count decreased
Right ventricular failure (right half of the heart fails to work)
Hypoacusis (loss of hearing)
Impaired healing
Skin ulcer
Anaemia (lack of blood)
Arthralgia (joint pain)
Interstitial lung disease
Muscle rigidity (muscle stiffness)

50-59:

Temperature regulation disorder (body is unable to maintain temperature)
Burning sensation
Lung disorder (lung disease)
Thrombosis (formation of a blood clot inside a blood vessel)
Vertigo
Cough
Dyspnoea (difficult or laboured respiration)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

60+:

Anaemia (lack of blood)
Headache (pain in head)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Scleroderma (hard skin)
Left ventricular failure (left ventricle fails to contract forcefully)
Oedema peripheral (superficial swelling)
Pyrexia (fever)
Lymphoma (cancer that begins in immune system cells)
White blood cell count decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 32 people, 65.31%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 20.41%
Depression: 9 people, 18.37%
High Blood Cholesterol: 9 people, 18.37%
Dyslipidaemia (abnormal amount of lipids): 8 people, 16.33%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 7 people, 14.29%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 14.29%
Dry Eyes (lack of adequate tears): 7 people, 14.29%
Irritable Bowel Syndrome: 7 people, 14.29%
Cardiac Failure: 7 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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