Amitriptyline hydrochloride and Aredia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Aredia (pamidronate disodium). Common drug interactions include fatigue among females and osteonecrosis of jaw among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Aredia. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Aredia?

Aredia has active ingredients of pamidronate disodium. It is often used in breast cancer. eHealthMe is studying from 15,364 Aredia users. Check the latest studies of Aredia.

On Jul, 15, 2026

39 people who take Amitriptyline hydrochloride and Aredia together, and have interactions are studied.

Amitriptyline hydrochloride and Aredia drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Aredia, by gender? *:

female:

Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Arthralgia (joint pain)
Cellulitis (infection under the skin)
Headache (pain in head)
Back pain
Decreased appetite
Fall
Tooth extraction

male:

Osteonecrosis of jaw (death of bone of jaw)
Anaemia (lack of blood)
Arthralgia (joint pain)
Decreased interest
General physical health deterioration (weak health status)
Headache (pain in head)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Pain in jaw
Bone pain
Chest pain

What are the common drug interactions of Amitriptyline Hydrochloride and Aredia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Cellulitis (infection under the skin)
Chest pain
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Constipation
Decreased interest
General physical health deterioration (weak health status)
Lung neoplasm (tumour of lung)
Nausea (feeling of having an urge to vomit)
Osteomyelitis (infection of bone)

40-49:

Bone disorder
Anxiety
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Back pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Impaired healing
Tooth extraction
Alveolar osteitis (complication of wound healing following extraction of a tooth)

50-59:

Nausea (feeling of having an urge to vomit)
Bone pain
Cellulitis (infection under the skin)
Fall
Injury
Oedema peripheral (superficial swelling)
Anaemia (lack of blood)
Osteomyelitis (infection of bone)
Constipation
Cough

60+:

Pain
Fatigue (feeling of tiredness)
Weight decreased
Stomatitis (inflammation of mucous membrane of mouth)
Arthralgia (joint pain)
Decreased interest
General physical health deterioration (weak health status)
Pain in jaw
Pneumonia
Rash

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 10 people, 25.64%
Multiple Myeloma (cancer of the plasma cells): 6 people, 15.38%
Pain: 4 people, 10.26%
Osteomyelitis (infection of bone): 4 people, 10.26%
Bone Cancer Metastatic: 4 people, 10.26%
Depression: 3 people, 7.69%
Resorption Bone Increased: 2 people, 5.13%
Osteoporosis (bones weak and more likely to break): 2 people, 5.13%
Osteolysis (dissolution of bone): 2 people, 5.13%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Amitriptyline hydrochloride and Aredia?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously