Amitriptyline hydrochloride and Bactrim ds drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Bactrim ds (sulfamethoxazole; trimethoprim). Common drug interactions include gallbladder disorder among females and device failure among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Bactrim ds. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Bactrim ds?

Bactrim ds has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 17,027 Bactrim ds users. Check the latest studies of Bactrim ds.

On Aug, 06, 2026

40 people who take Amitriptyline hydrochloride and Bactrim ds together, and have interactions are studied.

Amitriptyline hydrochloride and Bactrim ds drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Bactrim Ds, by gender? *:

female:

Gallbladder disorder
Gastritis (inflammation of stomach)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Gastrointestinal infection (infection of stomach and intestine)
Genital infection bacterial
Glycosylated haemoglobin increased
Head discomfort
Heart rate increased
Hepatic cyst
Hepatic steatosis (fatty liver disease)

male:

Device failure
Acquired immunodeficiency syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv))
Cardiomyopathy (weakening of the heart muscle)
Cataract (clouding of the lens inside the eye)
Death
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematocrit decreased
Haemoglobin decreased
Hypersomnia (excessive daytime sleepiness (eds))
Neutropenia (an abnormally low number of neutrophils)

What are the common drug interactions of Amitriptyline Hydrochloride and Bactrim Ds, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pulmonary embolism (blockage of the main artery of the lung)

20-29:

Asthenia (weakness)
Cardiac failure
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematocrit decreased
Haemoglobin decreased
Hypersomnia (excessive daytime sleepiness (eds))
Pericarditis constrictive (inflammation of the pericardium-constrictive)
Pneumonia

30-39:

Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Disease progression

40-49:

Fatigue (feeling of tiredness)
Genital infection bacterial
Head discomfort
Heart rate increased
Hypertension (high blood pressure)
Immunosuppression
Inflammation
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Neuralgia (pain in one or more nerves)

50-59:

Chronic kidney disease
Dyspepsia (indigestion)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Acquired immunodeficiency syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv))
Ascites (accumulation of fluid in the abdominal cavity)
Blood cholesterol increased
Drug hypersensitivity
Hepatitis c

60+:

Device failure
Chronic kidney disease
Infusion site pruritus (severe itching at infusion site)
Infusion site swelling
Neutropenia (an abnormally low number of neutrophils)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Scleroderma (hard skin)
Cataract (clouding of the lens inside the eye)
Headache (pain in head)
Infusion site discolouration

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 17.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 15.00%
Depression: 5 people, 12.50%
Drowsiness: 5 people, 12.50%
Infection: 4 people, 10.00%
High Blood Pressure: 4 people, 10.00%
Pain: 4 people, 10.00%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 10.00%
Inflammation: 4 people, 10.00%
Nausea (feeling of having an urge to vomit): 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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