Amitriptyline hydrochloride and Pegasys drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Pegasys (peginterferon alfa 2a). Common drug interactions include fatigue among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Pegasys. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Pegasys?

Pegasys has active ingredients of peginterferon alfa 2a. It is often used in hepatitis c. eHealthMe is studying from 57,446 Pegasys users. Check the latest studies of Pegasys.

On Jul, 29, 2026

22 people who take Amitriptyline hydrochloride and Pegasys together, and have interactions are studied.

Amitriptyline hydrochloride and Pegasys drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Pegasys, by gender? *:

female:

Fatigue (feeling of tiredness)
Platelet count decreased
Anal abscess
Bartholin's abscess (infection of one or both of the two bartholin's glands, which are located one on either side of the opening of the vagina)
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Nausea (feeling of having an urge to vomit)
Pneumonia
Psoriasis (immune-mediated disease that affects the skin)
Anaemia (lack of blood)

male:

Fatigue (feeling of tiredness)
Decreased appetite
Platelet count decreased
Red blood cell count decreased
White blood cell count decreased
Balance disorder
Full blood count decreased
Haemoglobin increased
Influenza like illness
Pruritus (severe itching of the skin)

What are the common drug interactions of Amitriptyline Hydrochloride and Pegasys, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Excitability
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Panic disorder
Psychiatric symptom
Restlessness (not able to rest)
Somatisation disorder (a long-term (chronic) condition in which a person has physical symptoms that involve more than one part of the body)

30-39:

n/a

40-49:

Anaemia (lack of blood)
Platelet count decreased
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Osteopenia (a condition where bone mineral density is lower than normal)

50-59:

Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Arthralgia (joint pain)
Decreased appetite
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dyspnoea (difficult or laboured respiration)
Flatulence (flatus expelled through the anus)
Gastrointestinal pain

60+:

Fatigue (feeling of tiredness)
Decreased appetite
Platelet count decreased
Red blood cell count decreased
White blood cell count decreased
Balance disorder
Drug ineffective
Full blood count decreased
Haemoglobin increased
Influenza like illness

What are the existing conditions these people have? *

Insomnia (sleeplessness): 5 people, 22.73%
Depression: 5 people, 22.73%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.64%
Stress And Anxiety: 2 people, 9.09%
Nausea (feeling of having an urge to vomit): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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