Amitriptyline hydrochloride and Robaxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Robaxin (methocarbamol). Common drug interactions include bronchial irritation among females and alcoholism among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Robaxin. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Robaxin?

Robaxin has active ingredients of methocarbamol. It is often used in muscle spasms. eHealthMe is studying from 9,109 Robaxin users. Check the latest studies of Robaxin.



On Jul, 20, 2026

50 people who take Amitriptyline hydrochloride and Robaxin together, and have interactions are studied.

Amitriptyline hydrochloride and Robaxin drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Robaxin, by gender? *:

female:

  1. Bronchial irritation
  2. Cellulitis (infection under the skin)
  3. Constipation
  4. Cystitis interstitial (unknown cause characterized by bladder pain)
  5. Dyspnoea (difficult or laboured respiration)
  6. Cystitis (inflammation of the wall of the bladder)
  7. Pain
  8. Small intestinal obstruction (blockage in small intestine)
  9. Anaemia (lack of blood)
  10. Obstruction

male:

  1. Alcoholism (problems with alcohol)
  2. Alopecia (absence of hair from areas of the body)
  3. Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
  4. Pancreatitis (inflammation of pancreas)
  5. Pneumonia
  6. Polysubstance dependence
  7. Shared psychotic disorder (a mental illness that causes abnormal thinking and perceptions)
  8. Substance abuse
  9. Suicidal ideation
  10. Type 2 diabetes mellitus

What are the common drug interactions of Amitriptyline Hydrochloride and Robaxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Alcoholism (problems with alcohol)
  2. Alopecia (absence of hair from areas of the body)
  3. Dysthymic disorder (mild chronic depression disorder)
  4. Gastroenteritis (inflammation of stomach and intestine)
  5. Head injury
  6. Hepatitis c
  7. Hypotension (abnormally low blood pressure)
  8. Hypoxia (low oxygen in tissues)
  9. Localised infection (infection at the single location)
  10. Loss of consciousness

30-39:

  1. Abdominal pain
  2. Alveolar osteitis (complication of wound healing following extraction of a tooth)
  3. Anaemia (lack of blood)
  4. Anxiety
  5. Appendicitis (inflammation of the appendix)
  6. Arthropathy
  7. Asthma
  8. Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
  9. Bone pain
  10. Breast cancer recurrent

40-49:

  1. Amputation
  2. Anxiety
  3. Hypersensitivity
  4. Irritability

50-59:

  1. Back disorder
  2. Balance disorder
  3. Bladder dysfunction
  4. Blood disorder
  5. Bruxism (habitual grinding of the teeth, typically during sleep)
  6. Burning sensation
  7. Contusion (a type of hematoma of tissue in which capillaries)
  8. Disturbance in attention
  9. Dysphagia (a condition in which swallowing is difficult or painful)
  10. Dysphonia (speech disorder attributable to a disorder of phonation)

60+:

  1. Small intestinal obstruction (blockage in small intestine)
  2. Blood pressure fluctuation
  3. Hypertension (high blood pressure)
  4. Joint injury
  5. Cough
  6. Headache (pain in head)
  7. Sinusitis (inflammation of sinus)
  8. Abdominal mass (localized enlargement or swelling in the human abdomen)
  9. Abdominal pain
  10. Anal fissure

What are the existing conditions these people have? *

  1. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 28 people, 56.00%
  2. Urinary Tract Infection: 12 people, 24.00%
  3. Blood Iron Decreased: 9 people, 18.00%
  4. Immunodeficiency Common Variable: 5 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Amitriptyline hydrochloride and Robaxin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Amitriptyline hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Robaxin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Amitriptyline hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Robaxin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on amitriptyline hydrochloride and methocarbamol (the active ingredients of Amitriptyline hydrochloride and Robaxin, respectively), and Amitriptyline hydrochloride and Robaxin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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