Amitriptyline hydrochloride and Viibryd drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Viibryd (vilazodone hydrochloride). Common drug interactions include abdominal discomfort among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Viibryd. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Viibryd?

Viibryd has active ingredients of vilazodone hydrochloride. It is often used in depression. eHealthMe is studying from 11,106 Viibryd users. Check the latest studies of Viibryd.

On Aug, 06, 2026

15 people who take Amitriptyline hydrochloride and Viibryd together, and have interactions are studied.

Amitriptyline hydrochloride and Viibryd drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Viibryd, by gender? *:

female:

Abdominal discomfort
Disability
Intervertebral disc protrusion (spinal disc protrusion)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Chronic kidney disease
Renal injury (kidney injury)
Accident
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Coeliac disease (simple food intolerance)

male:

Asthenia (weakness)
Burning sensation
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Urinary tract infection
Vertigo
Weight decreased
Erythema (redness of the skin)
Fall
Gait disturbance
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)

What are the common drug interactions of Amitriptyline Hydrochloride and Viibryd, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Asthenia (weakness)
Burning sensation
Erythema (redness of the skin)
Fall
Gait disturbance
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Muscle spasms (muscle contraction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Chronic kidney disease
Renal injury (kidney injury)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Weight decreased

60+:

Abdominal discomfort
Blood pressure increased
Sinus disorder (disease of sinus)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Coeliac disease (simple food intolerance)
Disability
Drug ineffective
Heart rate decreased
Hospitalisation
Intervertebral disc protrusion (spinal disc protrusion)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 60.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 53.33%
Drowsiness: 4 people, 26.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 20.00%
Neuropathy Peripheral (surface nerve damage): 1 person, 6.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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