Anaprox and Lomotil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Anaprox (naproxen sodium) and Lomotil (atropine sulfate; diphenoxylate hydrochloride). Common drug interactions include bronchitis among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Anaprox and Lomotil. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Anaprox?

Anaprox has active ingredients of naproxen sodium. eHealthMe is studying from 1,370 Anaprox users. Check the latest studies of Anaprox.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.



On Jul, 11, 2026

14 people who take Anaprox and Lomotil together, and have interactions are studied.

Anaprox and Lomotil drug interactions.

What are the common drug interactions of Anaprox and Lomotil, by gender? *:

female:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Cancer pain
  3. Cervical spinal stenosis (narrowing of the spinal canal in the neck)
  4. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  5. Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
  6. Constipation
  7. Decreased appetite
  8. Depression
  9. Device related infection
  10. Dysphagia (a condition in which swallowing is difficult or painful)

male:

  1. Abdominal pain
  2. Abdominal wound dehiscence (abdominal wound ruptures)
  3. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  4. Cervical spinal stenosis (narrowing of the spinal canal in the neck)
  5. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  6. Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
  7. Constipation
  8. Decreased appetite
  9. Depression
  10. Device related infection

What are the common drug interactions of Anaprox and Lomotil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Abdominal pain
  2. Arthralgia (joint pain)
  3. Gait disturbance
  4. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  5. Urticaria (rash of round, red welts on the skin that itch intensely)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Acute leukaemia (blood cancer)
  2. Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
  3. Hepatic failure (liver failure)
  4. Hepatic neoplasm malignant (liver cancer)
  5. Inflammation
  6. Liver fatty (fat deposition of liver)
  7. Altered state of consciousness (altered state of mind)
  8. Anaemia (lack of blood)
  9. Anxiety
  10. Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)

60+:

  1. Cough
  2. Headache (pain in head)
  3. Malaise (a feeling of general discomfort or uneasiness)
  4. Nasopharyngitis (inflammation of the nasopharynx)
  5. Neoplasm progression (growth of tumour)
  6. Platelet count decreased
  7. White blood cell count decreased

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 50.00%
  2. Pain: 2 people, 14.29%
  3. Depression: 2 people, 14.29%
  4. Wheezing (a high-pitched whistling sound made while you breath): 1 person, 7.14%
  5. Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 7.14%
  6. Asthma: 1 person, 7.14%
  7. Breast Cancer Female: 1 person, 7.14%
  8. Breast Cancer Metastatic: 1 person, 7.14%
  9. Breast Cancer Stage Iv: 1 person, 7.14%
  10. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Anaprox and Lomotil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Anaprox and Lomotil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Anaprox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lomotil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Anaprox and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lomotil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium and atropine sulfate; diphenoxylate hydrochloride (the active ingredients of Anaprox and Lomotil, respectively), and Anaprox and Lomotil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: