Ancef and Prohance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ancef (cefazolin sodium) and Prohance (gadoteridol). Common drug interactions include anhedonia among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Ancef and Prohance. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Ancef?

Ancef has active ingredients of cefazolin sodium. eHealthMe is studying from 3,292 Ancef users. Check the latest studies of Ancef.

What is Prohance?

Prohance has active ingredients of gadoteridol. eHealthMe is studying from 3,734 Prohance users. Check the latest studies of Prohance.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

11 people who take Ancef and Prohance together, and have interactions are studied.

What are the common drug interactions of Ancef and Prohance, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dry skin
Joint range of motion decreased (disease of joint movement)
Muscular weakness (muscle weakness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pain
Pruritus (severe itching of the skin)

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Pruritus (severe itching of the skin)
Skin discolouration (change of skin colour)
Stasis dermatitis (skin inflammation caused by blood pooling in the veins in your legs)
Depression
Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers)
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Ischaemic ulcer (arterial ulcer)

What are the common drug interactions of Ancef and Prohance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Drug ineffective

60+:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pruritus (severe itching of the skin)
Skin discolouration (change of skin colour)
Depression
Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers)
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Ischaemic ulcer (arterial ulcer)
Joint contracture (a permanent shortening of a muscle or joint)

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 6 people, 54.55%
Rash Pruritic (redness with itching): 3 people, 27.27%
Tenderness (pain or discomfort when an affected area is touched): 1 person, 9.09%
Swelling: 1 person, 9.09%
Staphylococcal Infection (an infection with staphylococcus bacteria): 1 person, 9.09%
Pain: 1 person, 9.09%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 1 person, 9.09%
Hypotension (abnormally low blood pressure): 1 person, 9.09%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 1 person, 9.09%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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