Anzemet and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Anzemet (dolasetron mesylate) and Zide (hydrochlorothiazide). Common drug interactions include bone disorder among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Anzemet and Zide. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Anzemet?

Anzemet has active ingredients of dolasetron mesylate. eHealthMe is studying from 2,603 Anzemet users. Check the latest studies of Anzemet.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Aug, 05, 2026

78 people who take Anzemet and Zide together, and have interactions are studied.

What are the common drug interactions of Anzemet and Zide, by gender? *:

female:

Bone disorder
Lymphadenopathy (disease or enlargement of lymph nodes)
Osteolysis (dissolution of bone)
Abscess (pus)
Asthenia (weakness)
Cataract (clouding of the lens inside the eye)
Cough
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Intervertebral disc protrusion (spinal disc protrusion)

male:

Diarrhoea
Blood sodium decreased
Renal failure (kidney dysfunction)
Vomiting
Blood glucose increased
Blood potassium decreased
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematocrit decreased

What are the common drug interactions of Anzemet and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abscess (pus)
Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)
Arthropathy
Back pain
Blood cholesterol increased
Bone disorder
Breast cyst
Breast mass
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

30-39:

n/a

40-49:

Anxiety
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Intervertebral disc protrusion (spinal disc protrusion)
Oedema peripheral (superficial swelling)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Pathological fracture (broken bone caused by disease)
Spinal osteoarthritis (joint cartilage loss in spine)

50-59:

Arthralgia (joint pain)
Bone disorder
Nausea (feeling of having an urge to vomit)
Osteopenia (a condition where bone mineral density is lower than normal)
Swelling
Tooth extraction
Vomiting
Fatigue (feeling of tiredness)
Lymphadenopathy (disease or enlargement of lymph nodes)
Neutropenia (an abnormally low number of neutrophils)

60+:

Diarrhoea
Pyrexia (fever)
Pain
Urinary tract infection
Abscess jaw (tooth abscess or root abscess)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Bladder cancer recurrent

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 13 people, 16.67%
Lung Cancer - Non-Small Cell (lung cancer): 7 people, 8.97%
Resorption Bone Increased: 6 people, 7.69%
Pain: 5 people, 6.41%
Sleep Disorder: 4 people, 5.13%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 4 people, 5.13%
Breast Cancer Female: 4 people, 5.13%
Breast Cancer: 4 people, 5.13%
Bone Density Decreased: 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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