Apple cider vinegar and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Apple cider vinegar (apple cider vinegar) and Melatonin (melatonin). Common drug interactions include mania among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Apple cider vinegar and Melatonin. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Apple cider vinegar?

Apple cider vinegar has active ingredients of apple cider vinegar. It is often used in weight loss. eHealthMe is studying from 1,380 Apple cider vinegar users. Check the latest studies of Apple cider vinegar.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 13, 2026

96 people who take Apple cider vinegar and Melatonin together, and have interactions are studied.

Apple cider vinegar and Melatonin drug interactions.

What are the common drug interactions of Apple Cider Vinegar and Melatonin, by gender? *:

female:

Mania (a state of abnormally elevated or irritable mood)
Memory impairment
Muscle spasms (muscle contraction)
Neurotransmitter level altered
Sedation
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Depression
Disease progression
Dizziness

male:

Dehydration (dryness resulting from the removal of water)
Bipolar disorder (mood disorder)
Drug level decreased
Fatigue (feeling of tiredness)
Gait disturbance
Infusion site mass
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain
Procedural haemorrhage (procedural bleeding)
Dyspepsia (indigestion)

What are the common drug interactions of Apple Cider Vinegar and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal discomfort
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Feeling hot
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrointestinal pain
Hypotension (abnormally low blood pressure)
Muscle twitching
Nausea (feeling of having an urge to vomit)
Pallor

20-29:

Laryngitis (inflammation of the larynx)
Upper respiratory tract infection
Infusion site extravasation (flow of (blood or lymph) from infusion site)

30-39:

Headache (pain in head)
Oral herpes (viral infection of mouth)
Sinusitis (inflammation of sinus)
Fungal infection
Mastitis (inflammation of breast)
Uterine infection
Fatigue (feeling of tiredness)
Pruritus (severe itching of the skin)
Vulvovaginal mycotic infection (vulvovaginal fungal infection)
Cough

40-49:

Agitation (state of anxiety or nervous excitement)
Blood cholesterol increased
Cerebral disorder (brain disease)
Daydreaming
Drug dependence
Drug ineffective
Fatigue (feeling of tiredness)
Feeling hot
General physical health deterioration (weak health status)
Headache (pain in head)

50-59:

Neuropathy peripheral (surface nerve damage)
Oral candidiasis (fungal infection of mouth)
Oral pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic attack
Peripheral swelling
Peripheral vascular disorder
Photophobia (extreme sensitivity to light)
Pulmonary embolism (blockage of the main artery of the lung)
Rash

60+:

Fatigue (feeling of tiredness)
Diarrhoea
Gastric disorder (disease of stomach)
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Blood glucose increased
Arthralgia (joint pain)
Bladder cancer
Blood pressure increased
Cataplexy (loss of muscle tone accompanied by full conscious awareness)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 19 people, 19.79%
Ovarian Cancer (cancer of ovary): 8 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 7.29%
Depression: 7 people, 7.29%
Immunodeficiency: 6 people, 6.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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